ArticleNature communications2026
Visible light-mediated Alder-ene reaction of bicyclobutanes with cyclohexynes to access skipped dienes and skeletal remodeling to tetralines.
Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
2 authors.
Funding
Abstract
The strain-release driven reactions of bicyclo[1.1.0]butanes (BCBs) offer a powerful synthetic strategy for the construction of complex carbocyclic frameworks. Herein, we report the direct engagement of BCBs with transient cyclohexynes through a visible light-mediated dual-strain release manifold. By utilizing a photochemical peroxide precursor, this catalyst-free protocol bypasses the deleterious byproducts and super-stoichiometric fluoride sources typically required for cyclohexyne generation. This methodology allows the streamlined synthesis of skipped dienes bearing an all-carbon quaternary centre that are otherwise difficult to access via traditional means. The versatility of this reaction is underscored by its excellent functional group tolerance, scalability, and successfully extended to benzynes under mild and ambient conditions. Furthermore, the synthetic utility is demonstrated through the late-stage diversification of bioactive molecules and a synergistic S
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