Evidence map›Paper›PMID 42838556›Full record

ArticleProceedings. Biological sciences2026

Developmental bias of body size and caste by the fire ant social supergene.

Haolin Zeng, Corrie E Eidson, D Alekzandre Cushman, Mathews Nascimento, Beryl M Jones, Brendan G Hunt

Abstract read
In one paragraph

Article in Proceedings. Biological sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Haolin ZengDepartment of Entomology , University of Georgia, Athens, GA, USA.ORCID 0000-0002-9921-7335
Corrie E EidsonDepartment of Entomology , University of Georgia, Athens, GA, USA.
D Alekzandre CushmanDepartment of Entomology , University of Georgia, Athens, GA, USA.
Mathews NascimentoDepartment of Entomology , University of Georgia, Athens, GA, USA.
Beryl M JonesDepartment of Entomology, University of Kentucky , Lexington, KY, USA.ORCID 0000-0003-2925-0807
Brendan G HuntDepartment of Entomology , University of Georgia, Athens, GA, USA.ORCID 0000-0002-0030-9302

Funding

Gene regulatory network plasticity in social behaviorR35GM156952 · NIGMS · UNIVERSITY OF KENTUCKY · PI Beryl M Jones · 2025 to 2026
$730k
National Institutes of Health NIGMS R35GM156952National Science Foundation 1754476National Science Foundation 1755130National Science Foundation 2310983NIGMS NIH HHS R35 GM156952
6 · The paper itself

Abstract

Supergenes are clusters of linked genes that drive complex phenotypic divergence. In the fire ant Solenopsis invicta, a supergene determines polymorphic social organization, and its derived (b) haplotype is over-represented among large workers and gynes relative to the ancestral (B) haplotype, acting as a selfish genetic element. We tested whether this caste bias reflects altered juvenile hormone (JH) mediated growth by treating colonies with a JH analogue. We show that BB and Bb pupae reach similar maximal sizes and exhibit a comparable JH-mediated growth response despite consistent Bb over-representation in the upper size classes. We also used developmental gene expression data from another ant to reveal significantly enriched overlap between genes with differential expression by supergene genotype and orthologues with differential expression between gyne- and worker-destined larvae. This overlap could be shaped in part by observed cis-regulatory evolution of the supergene. Overall, our results are consistent with incompletely penetrant effects of a supergene on developmental trajectories linked to size-based caste allocation in a highly social insect.

Indexed as

AntsBody SizeFire AntsGenes, InsectAnimalsJuvenile HormonesLarvaPupaSocial BehaviorJuvenile Hormonesallosomegas8inversion polymorphismjuvenile hormoneselfish genetic elementsupergene

Identifiers

PMID42838556
PMCPMC13641908

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.