ArticleJMIR research protocols2026
Chitosan Nanoparticles Combined With Titanium-Prepared Platelet-Rich Fibrin for Socket Preservation in Postextraction Sites: Protocol for a Single-Arm Clinical, Radiographic, and Histomorphometric Study.
Article in JMIR research protocols, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundAlveolar ridge resorption following tooth extraction can compromise subsequent implant placement. Socket preservation techniques aim to minimize dimensional changes and promote favorable bone healing. Chitosan nanoparticles combined with titanium-prepared platelet-rich fibrin represent a biologically active approach to ridge preservation.
objectiveThis study aims to evaluate longitudinal changes in alveolar ridge dimensions and bone quality following socket preservation using chitosan nanoparticles combined with titanium-prepared platelet-rich fibrin.
methodsThis is a single-arm prospective clinical study involving systemically healthy participants requiring tooth extraction. Clinical, radiographic, and histomorphometric assessments will be performed at baseline and at follow-up visits at 3 and 6 months. Statistical analysis will be conducted using within-subject repeated-measures approaches.
resultsNo external funding was received for this research. The manuscript was submitted before recruitment of participants had started and no clinical data had been collected or analyzed. Clinical, radiographic, and histomorphometric outcomes will be evaluated to assess changes in the dimensions of the alveolar ridge, bone density, and quality of regenerated bone during the postextraction healing period. Clinical and radiographic evaluation will be performed at baseline, 3 months, and 6 months. Histomorphometric analysis will be performed on bone core biopsy samples taken at the time of implant placement. The results of the study will be reported after data collection and analysis.
conclusionsThis protocol outlines a standardized approach to evaluating the clinical, radiographic, and histomorphometric outcomes of socket preservation using chitosan nanoparticles combined with titanium-prepared platelet-rich fibrin. The findings from this study may inform the design of future controlled clinical trials.
trial registrationClinical Trials Registry of India CTRI/2025/06/089715; https://tinyurl.com/4u6698xs. INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): PRR1-10.2196/79532.
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