ArticleAmerican journal of physiology. Gastrointestinal and liver physiology2026
Sex- and hepatocyte PPARγ-dependent effects of an obesogenic dietary approach to induce MASH with fibrosis in mice.
Article in American journal of physiology. Gastrointestinal and liver physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Mouse models of metabolic dysfunction-associated steatotic liver disease (MASLD) are valuable tools for identifying novel molecular mechanisms that drive progression from MASLD to metabolic dysfunction-associated steatohepatitis (MASH). However, developing a robust MASLD/MASH mouse model with obesity and peripheral metabolic dysfunction remains a challenge. In this study, we have fed two different MASH-inducing diets to male mice with preexisting high-fat (HF) diet-induced obesity. Although an HF diet with 40% of kcal from fat (mostly corn-oil shortening), 2% cholesterol, and 22% fructose reduced adiposity in mice with preexisting obesity, a high-fat diet with 60% of kcal from fat (mostly lard), 2% cholesterol, and supplemented with 10% fructose in the drinking water (HFC + Fr diet) promoted body weight and fat mass gain. Of note, 24 wk of the HFC + Fr diet induced obesity, metabolic dysfunction, and liver steatosis and increased the expression of hepatic peroxisome proliferator-activated receptor γ (
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