Evidence map›Paper›PMID 42837445›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

Late-onset preeclampsia is characterized by accelerated placental aging.

Anya L Arthurs, Rudrarup Bhattacharjee, Melanie D Smith, Dulce L Medina Garcia, Ellen Menkhorst, German Mora, Jessica M Williamson, Lynda K Harris, Jose M Polo, David A MacIntyre and 1 more

Abstract read
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In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Anya L ArthursDiscipline of Women's and Children's Health, Flinders Health and Medical Research Institute, Flinders University, Adelaide, SA 5042, Australia.ORCID 0000-0002-4382-0610
Rudrarup BhattacharjeeRobinson Research Institute, University of Adelaide, Adelaide, SA 5000, Australia.ORCID 0000-0003-2740-6986
Melanie D SmithDiscipline of Women's and Children's Health, Flinders Health and Medical Research Institute, Flinders University, Adelaide, SA 5042, Australia.
Dulce L Medina GarciaAdelaide Centre for Epigenetics, School of Biomedicine, and South Australian Immunogenomics Cancer Institute, University of Adelaide, Adelaide, SA 5000, Australia.
Ellen MenkhorstDepartment of Obstetrics, Gynaecology and Newborn Health, University of Melbourne, Parkville, VIC 3010, Australia.ORCID 0000-0003-2440-6665
German MoraAdelaide Centre for Epigenetics, School of Biomedicine, and South Australian Immunogenomics Cancer Institute, University of Adelaide, Adelaide, SA 5000, Australia.
Jessica M WilliamsonDiscipline of Women's and Children's Health, Flinders Health and Medical Research Institute, Flinders University, Adelaide, SA 5042, Australia.ORCID 0000-0002-6332-7874
Lynda K HarrisDepartment of Obstetrics and Gynaecology, University of Nebraska Medical Center, Omaha, NE 68198.
Jose M PoloAdelaide Centre for Epigenetics, School of Biomedicine, and South Australian Immunogenomics Cancer Institute, University of Adelaide, Adelaide, SA 5000, Australia.
David A MacIntyreRobinson Research Institute, University of Adelaide, Adelaide, SA 5000, Australia.ORCID 0000-0002-4186-5567
Claire T RobertsDiscipline of Women's and Children's Health, Flinders Health and Medical Research Institute, Flinders University, Adelaide, SA 5042, Australia.

Funding

Maternal molecular profiles reflect placental function and development across gestationR01HD089685 · NICHD · UNIVERSITY OF ADELAIDE · PI ROBERTS, CLAIRE · 2016 to 2019
$953k
Channel 7 Children's Research Foundation (CRF) N/ADHAC | National Health and Medical Research Council (NHMRC) GNT1174971Flinders Foundation N/AFlinders University (The Flinders University of South Australia) N/AFoundation for the NIH (FNIH) NICHD R01 HD089685-01NICHD NIH HHS R01 HD089685University of Adelaide (UoA) N/A
6 · The paper itself

Abstract

Late-onset preeclampsia (LOPE) is a major pregnancy complication characterized by hypertension and placental dysfunction, resolving only upon delivery. Here, we show that LOPE placentae undergo accelerated molecular aging, marked by telomere attrition, DNA damage, and trophoblast senescence. Using primary placental tissue and trophoblast organoids, we demonstrate oxidative stress as a driver of telomere shortening and angiogenic imbalance. Inflammation did not alter placental aging trajectories. Antioxidant treatment (superoxide dismutase) preserved telomere length, reduced DNA damage, and restored angiogenic balance, highlighting oxidative stress as a modifiable determinant of placental aging. We identify reduced expression of telomeric repeat-containing RNAs (TERRAs) as a molecular hallmark of LOPE, and show that antisense oligonucleotide-mediated TERRA depletion exacerbates telomere erosion and senescence. Together, these findings delineate oxidative stress and TERRA loss as mechanisms driving placental decline, establish trophoblast organoids as a tractable model of placental aging, and reveal potential therapeutic avenues for mitigating preeclampsia-associated placental dysfunction.

Indexed as

AgingPlacentaPre-EclampsiaCellular SenescenceDNA DamageFemaleHumansOxidative StressPregnancyRNA, Long NoncodingTelomereTelomere ShorteningTrophoblastsRNA, Long Noncodingaginginflammationoxidative stressplacentapreeclampsia

Identifiers

PMID42837445
PMCPMC13663791

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.