Evidence map›Paper›PMID 42837080›Full record

ArticleUpdates in surgery2026

Obesity and pathological features of tumour aggressiveness and lymph node staging in colon cancer: a multicentre propensity score-matched study.

Marta Goglia, Mattia Leonardo Giancola, Gabriella Distefano, Francesco Maria Carrano, Marco Catarci, Marcello Gasparrini, Paolo Mercantini, Roberto Santoro, Gianfranco Silecchia

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Article in Updates in surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Marta GogliaDepartment of Medical Surgical Sciences and Translational Medicine, Faculty of Medicine and Psychology, Sapienza University of Rome, Via di Grottarossa 1035, Rome, 00189, Italy. marta.goglia@uniroma1.it.ORCID http://orcid.org/0000-0002-3763-8847
Mattia Leonardo GiancolaDepartment of Medical Surgical Sciences and Translational Medicine, Faculty of Medicine and Psychology, Sapienza University of Rome, Via di Grottarossa 1035, Rome, 00189, Italy.
Gabriella DistefanoDepartment of Medical Surgical Sciences and Translational Medicine, Faculty of Medicine and Psychology, Sapienza University of Rome, Via di Grottarossa 1035, Rome, 00189, Italy.
Francesco Maria CarranoDepartment of Medical Surgical Sciences and Translational Medicine, Faculty of Medicine and Psychology, Sapienza University of Rome, Via di Grottarossa 1035, Rome, 00189, Italy.
Marco CatarciGeneral Surgery Unit, Sandro Pertini Hospital, Rome, Italy.
Marcello GasparriniDepartment of Medical Surgical Sciences and Translational Medicine, Faculty of Medicine and Psychology, Sapienza University of Rome, Via di Grottarossa 1035, Rome, 00189, Italy.
Paolo MercantiniDepartment of Medical Surgical Sciences and Translational Medicine, Faculty of Medicine and Psychology, Sapienza University of Rome, Via di Grottarossa 1035, Rome, 00189, Italy.
Roberto SantoroIRCSS-Regina Elena National Cancer Institute, Rome, Italy.
Gianfranco SilecchiaDepartment of Medical Surgical Sciences and Translational Medicine, Faculty of Medicine and Psychology, Sapienza University of Rome, Via di Grottarossa 1035, Rome, 00189, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo investigate whether obesity (BMI ≥ 30) influences pathological markers of tumour aggressiveness and lymph node staging quality (≥ 12 retrieved nodes) in patients undergoing elective colon cancer surgery.

methodsThis multicentre retrospective cohort study included adults undergoing elective surgery for colon adenocarcinoma at three tertiary referral centres. Patients with rectal cancer, emergency surgery, metastatic disease, neoadjuvant therapy, or incomplete data were excluded. Obesity was defined as a BMI ≥ 30 kg/m². Clinical, surgical, and pathological data were collected from prospectively maintained databases. Associations between obesity and study outcomes were evaluated using multivariable logistic regression adjusted for age, sex, ASA score, tumour location, T stage, and MSI status.

resultsA total of 126 patients undergoing elective surgery for colon adenocarcinoma were included, of whom 42 (33.3%) BMI > 30. Obesity was not associated with lymphovascular invasion, tumour necrosis, or high-grade histology. In contrast, obesity independently predicted both perineural invasion (OR 3.59, 95%CI 1.16-11.50; p = 0.011) and peritumoral deposits (OR 2.82, 95%CI 1.03-7.69; p = 0.032). Higher T stage correlated with aggressive pathological features, whereas MSI status showed a protective effect. Regarding lymph node assessment, the proportion of patients with ≥ 12 retrieved nodes was high and similar between obese and non-obese patients (88.1% vs. 83.3%, p = 0.48). Obesity was not independently associated with adequate lymph node staging (OR 1.48, 95%CI 0.50-4.43; p = 0.48).

conclusionObesity did not compromise nodal staging or most tumour aggressiveness markers, but its association with perineural invasion and tumour deposits highlights a potentially distinct, clinically relevant tumour biology.

Indexed as

Colon cancerObesityPrecision medicineTumour aggressiveness

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PMID42837080

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