Evidence map›Paper›PMID 42837050›Full record

ArticleMagma (New York, N.Y.)2026

Feasibility of angiographic imaging using fast 3D Magnetic Resonance Spin TomogrAphy in Time-domain (MR-STAT).

Martin Bastiaan Schilder, Edwin Versteeg, Stefano Mandija, Oscar van der Heide, Fei Xu, Jan Willem Dankbaar, Mervyn Driek Ingmar Vergouwen, Ynte Marije Ruigrok, Irene van der Schaaf, Cornelis Antonius Theodorus van den Berg and 1 more

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Article in Magma (New York, N.Y.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Martin Bastiaan SchilderDepartment of Radiotherapy, Computational Imaging Group for MRI Therapy and Diagnostics, University Medical Center Utrecht, Heidelberglaan 100, 3584CX, Utrecht, The Netherlands. m.b.schilder-2@umcutrecht.nl.ORCID http://orcid.org/0009-0003-4058-4928
Edwin VersteegDepartment of Radiotherapy, Computational Imaging Group for MRI Therapy and Diagnostics, University Medical Center Utrecht, Heidelberglaan 100, 3584CX, Utrecht, The Netherlands.
Stefano MandijaDepartment of Radiotherapy, Computational Imaging Group for MRI Therapy and Diagnostics, University Medical Center Utrecht, Heidelberglaan 100, 3584CX, Utrecht, The Netherlands.
Oscar van der HeideDepartment of Radiotherapy, Computational Imaging Group for MRI Therapy and Diagnostics, University Medical Center Utrecht, Heidelberglaan 100, 3584CX, Utrecht, The Netherlands.
Fei XuDepartment of Radiotherapy, Computational Imaging Group for MRI Therapy and Diagnostics, University Medical Center Utrecht, Heidelberglaan 100, 3584CX, Utrecht, The Netherlands.
Jan Willem DankbaarDepartment of Radiology and Nuclear Medicine, University Medical Center Utrecht, Utrecht, The Netherlands.
Mervyn Driek Ingmar VergouwenDepartment of Neurology and Neurosurgery, University Medical Center Utrecht, UMC Utrecht Brain Center, Utrecht, The Netherlands.
Ynte Marije RuigrokDepartment of Neurology and Neurosurgery, University Medical Center Utrecht, UMC Utrecht Brain Center, Utrecht, The Netherlands.
Irene van der SchaafDepartment of Radiology and Nuclear Medicine, University Medical Center Utrecht, Utrecht, The Netherlands.
Cornelis Antonius Theodorus van den BergDepartment of Radiotherapy, Computational Imaging Group for MRI Therapy and Diagnostics, University Medical Center Utrecht, Heidelberglaan 100, 3584CX, Utrecht, The Netherlands.
Alessandro SbrizziDepartment of Radiotherapy, Computational Imaging Group for MRI Therapy and Diagnostics, University Medical Center Utrecht, Heidelberglaan 100, 3584CX, Utrecht, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate how angiographic information can be obtained from proton density (PD) maps reconstructed with a fast 3D Magnetic Resonance Spin TomogrAphy in Time-domain (MR-STAT) protocol, focusing on intracranial vessels and aneurysms in a clinically relevant population. MATERIALS AND

methodsThis proof-of-concept study consisted of two experiments. First, a healthy volunteer underwent MR-STAT with selective and non-selective excitation to investigate the origin of elevated effective proton density in arteries. Second, ten patients with intracranial aneurysms underwent 3D MR-STAT and time-of-flight MR angiography (TOF MRA). Two neuroradiologists independently assessed vessel visibility, image quality, and aneurysm size. Intraclass correlation coefficients (ICC) were computed for aneurysm size measurements.

resultsSelective excitation amplified inflow effects and yielded increased artery-tissue contrast in PD maps. Major intracranial arteries were visible in all clinical MR-STAT angiographic datasets. Nine out of ten MR-STAT angiographies were rated as at least diagnostically acceptable. Aneurysm measurements showed strong agreement between conventional and MR-STAT angiographic modalities (ICC=0.86/ICC=0.71) and high inter-rater reliability (ICC=0.90/ICC=0.92). DISCUSSION: MR-STAT PD maps enable angiographic visualization as an intrinsic component of a single fast quantitative acquisition, demonstrating technical feasibility for vessel depiction. Future work should focus on optimizing MR-STAT acquisition strategies to improve vessel conspicuity and broader clinical validation.

Indexed as

Intracranial aneurysmMagnetic resonance angiographyMR-STATQuantitative MRI

Identifiers

PMID42837050

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.