Evidence map›Paper›PMID 42836957›Full record

ArticleMedicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents2026

Bicyclononane-2,8-bis(trifluoromethyl)quinoline hybrids: synthesis, antiplasmodial and antitrypanosomal activity.

Johanna Dolensky, Werner Seebacher, Eva-Maria Pferschy-Wenzig, Miriam Zehentner, Robert Saf, Pascal Mäser, Monica Cal, Robert Weis

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Article in Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Johanna DolenskyPharmaceutical Chemistry, Institute of Pharmaceutical Sciences, University of Graz, Schubertstraße 1, Graz, A-8010, Austria.
Werner SeebacherPharmaceutical Chemistry, Institute of Pharmaceutical Sciences, University of Graz, Schubertstraße 1, Graz, A-8010, Austria.
Eva-Maria Pferschy-WenzigPharmacognosy, Institute of Pharmaceutical Sciences, University of Graz, Beethovenstraße 8, Graz, A-8010, Austria.
Miriam ZehentnerPharmacognosy, Institute of Pharmaceutical Sciences, University of Graz, Beethovenstraße 8, Graz, A-8010, Austria.
Robert SafInstitute for Chemistry and Technology of Materials (ICTM), Graz University of Technology, Stremayrgasse 9, Graz, 8010, Austria.
Pascal MäserSwiss Tropical and Public Health Institute, Kreuzstraße 2, Allschwil, CH-4123, Switzerland.
Monica CalSwiss Tropical and Public Health Institute, Kreuzstraße 2, Allschwil, CH-4123, Switzerland.
Robert WeisPharmaceutical Chemistry, Institute of Pharmaceutical Sciences, University of Graz, Schubertstraße 1, Graz, A-8010, Austria. robert.weis@uni-graz.at.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

With the aim to design dual-acting antiprotozoals, a set of hybrid-molecules was prepared. Amino-substituted 2-aza- and 3-azabicyclo[3.2.2]nonanes with antiplasmodial and antitrypanosomal activity were linked via aminoalkyl linkers to the 2,8-bis(trifluoromethyl)quinoline scaffold of mefloquine. All newly synthesized compounds were characterized by IR spectroscopy, NMR spectroscopy, and HRMS. Their antiplasmodial activities were examined in vitro against the NF54 strain of Plasmodium falciparum and their antitrypanosomal activity against the STIB900 strain of Trypanosoma brucei rhodesiense. Most of the compounds showed antiprotozoal activity in submicromolar concentration. Structure-activity relationships concerning the linker length as well as the amino substituent and ring position of the nitrogen in the bicyclic ring system were discussed. The most promising of the newly synthesized compounds was a 2-azabicyclononane with an aminopropyl linker and a 4-methylpiperazinyl substituent at a bridgehead atom. It showed excellent antiplasmodial and antitrypanosomal activity (IC

Indexed as

Bicyclic aminesHybridsMefloquinePlasmodium falciparumQuinolinesTrypanosoma brucei rhodesiense

Identifiers

PMID42836957

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.