Evidence map›Paper›PMID 42836922›Full record

ArticleJournal of molecular neuroscience : MN2026

Additive Enhancement of Neurovascular Regeneration and Functional Recovery by Combined MSC-Exosomes and Low-Intensity Pulsed Ultrasound in Ischemic Stroke Rats.

Tiefeng Li, Shuyu Lyu, Xinyu Yao, Ting Xia, Zuojun Geng, Defeng Liu, Huiling Yi, Jiecong Zhang, Ao Zhang, Qi Wang and 1 more

Abstract read
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In one paragraph

Article in Journal of molecular neuroscience : MN, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Tiefeng LiGraduate School, Hebei Medical University, Shijiazhuang, Hebei Province, 050017, China.
Shuyu LyuDepartment of Neurology, Beijing Luhe Hospital, Capital Medical University, Beijing, 110112, China.
Xinyu YaoThe First Hospital of Qinhuangdao, Qinhuangdao, Hebei Province, 066000, China.
Ting XiaRehabilitation Research Center, School of Rehabilitation, China Rehabilitation Science Institute, Capital Medical University, Beijing, 100071, China.
Zuojun GengThe Second Hospital of Hebei Medical University, Shijiazhuang, Hebei Province, 050000, China.
Defeng LiuThe First Hospital of Qinhuangdao, Qinhuangdao, Hebei Province, 066000, China.
Huiling YiThe First Hospital of Qinhuangdao, Qinhuangdao, Hebei Province, 066000, China.
Jiecong ZhangGraduate School, Hebei Medical University, Shijiazhuang, Hebei Province, 050017, China.
Ao ZhangGraduate School, Hebei Medical University, Shijiazhuang, Hebei Province, 050017, China.
Qi WangGraduate School, Hebei Medical University, Shijiazhuang, Hebei Province, 050017, China.
Lanxiang LiuThe First Hospital of Qinhuangdao, Qinhuangdao, Hebei Province, 066000, China. liulanxiang66@sina.com.

Funding

Qinhuangdao S&T Plan Program 202101A082S&T Program of Hebei 236Z7703G
6 · The paper itself

Abstract

Cerebral ischemic stroke (CIS) leads to high mortality and disability due to cerebrovascular obstruction. Current therapeutic approaches such as thrombolysis have limitations, and many patients suffer from long-term functional impairments, so new treatment strategies are urgently needed. Both low-intensity pulsed ultrasound (LIPUS) and mesenchymal stem cell-derived exosomes (MSC-EXOs) have demonstrated some therapeutic potential for CIS, but their efficacy is less pronounced when used alone. Therefore, this study aims to evaluate whether the combination of MSC-EXOs and LIPUS exerts an additive effect in the treatment of cerebral ischemic stroke. Adult rats subjected to middle cerebral artery occlusion (MCAO) were randomly assigned to sham, MCAO, MSC-EXO, LIPUS, or combination groups. Outcomes were assessed using the modified Neurological Severity Score (mNSS), corner and Y-maze tests, histological staining (HE and immunofluorescence), transmission electron microscopy (TEM), and quantitative real-time polymerase chain reaction (q-PCR). The combination group showed notable improvements in neurological function, with the highest proportion of cluster of differentiation 31 (CD31)/alpha-smooth muscle actin (α-SMA)/doublecortin (DCX)-positive immunofluorescence area, up-regulation of circular RNA SCMH-1(circSCMH-1), and the best restoration of synaptic ultrastructure. Compared with MSC-EXOs or LIPUS alone, the combined treatment appeared to have an additive effect, supporting neurovascular regeneration and functional recovery after cerebral ischemic stroke.

Indexed as

ExosomesInfarction, Middle Cerebral ArteryIschemic StrokeMesenchymal Stem CellsMesenchymal Stem Cell TransplantationNerve RegenerationUltrasonic TherapyUltrasonic WavesAnimalsDoublecortin ProteinMaleMicrotubule-Associated ProteinsRatsRats, Sprague-DawleyRecovery of FunctionDcx protein, ratDoublecortin ProteinMicrotubule-Associated ProteinsCircSCMH-1Low intensity ultrasonic stimulationMesenchymal stem cell exosomeNeurovascular regenerationNeurovascular unit

Identifiers

PMID42836922

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.