Evidence map›Paper›PMID 42836870›Full record

ArticleEuropean journal of applied physiology2026

Effects of isolated and combined supplementation of caffeine and capsaicin on a self-paced 10-km running performance.

Miércio Soares Melo, Francisco D 'Paula Vitor Ferreira, Matheus Hissa Lourenço Ferreira, Bruno Pena Couto, Fernanda Guimarães Drummond E Silva, Samuel Penna Wanner, Marcos Daniel Motta Drummond

Abstract read
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Article in European journal of applied physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Miércio Soares MeloSchool of Physical Education, Physical Therapy and Occupational Therapy (EEFFTO), Federal University of Minas Gerais (UFMG), Av. Pres. Antônio Carlos, 6627, Pampulha, Belo Horizonte, MG, 31270-901, Brazil. miercios@ufmg.br.ORCID http://orcid.org/0009-0006-1974-225X
Francisco D 'Paula Vitor FerreiraSchool of Physical Education, Physical Therapy and Occupational Therapy (EEFFTO), Federal University of Minas Gerais (UFMG), Av. Pres. Antônio Carlos, 6627, Pampulha, Belo Horizonte, MG, 31270-901, Brazil.ORCID http://orcid.org/0009-0003-6218-6744
Matheus Hissa Lourenço FerreiraSchool of Physical Education, Physical Therapy and Occupational Therapy (EEFFTO), Federal University of Minas Gerais (UFMG), Av. Pres. Antônio Carlos, 6627, Pampulha, Belo Horizonte, MG, 31270-901, Brazil.ORCID http://orcid.org/0009-0004-0371-1876
Bruno Pena CoutoSchool of Health, University of the Sunshine Coast, Sippy Downs, QLD, Australia.ORCID http://orcid.org/0000-0003-1011-6405
Fernanda Guimarães Drummond E SilvaNutrition Department, Federal University of Ouro Preto, Ouro Preto, Brazil.ORCID http://orcid.org/0000-0002-9615-5415
Samuel Penna WannerSchool of Physical Education, Physical Therapy and Occupational Therapy (EEFFTO), Federal University of Minas Gerais (UFMG), Av. Pres. Antônio Carlos, 6627, Pampulha, Belo Horizonte, MG, 31270-901, Brazil.ORCID http://orcid.org/0000-0002-4659-1032
Marcos Daniel Motta DrummondSchool of Physical Education, Physical Therapy and Occupational Therapy (EEFFTO), Federal University of Minas Gerais (UFMG), Av. Pres. Antônio Carlos, 6627, Pampulha, Belo Horizonte, MG, 31270-901, Brazil.ORCID http://orcid.org/0000-0002-5622-1297

Funding

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior 001
6 · The paper itself

Abstract

purposeTo investigate the acute effects of isolated and combined caffeine and capsaicin supplementation on performance and physiological, perceptual, and subjective responses during a self-paced 10-km run.

methodsThis randomized, double-masked, placebo-controlled crossover trial included 27 runners, of whom 20 (32.3 ± 8.2 years; 8 women, 12 men) completed four conditions: caffeine (CAF; 6 mg·kg⁻

resultsThe factorial model showed a significant main effect of caffeine on completion time (p = 0.0049), with no capsaicin effect or caffeine × capsaicin interaction. Pairwise comparisons showed a lower completion time only for CAF+CAP versus placebo (Tukey-adjusted p = 0.048; Dunnett-adjusted p = 0.028). Post-exercise blood lactate was higher with CAF+CAP than with all other conditions (all Tukey-adjusted p ≤ 0.022). Perceived vigor increased with CAF and CAF+CAP, while caffeine-containing conditions produced more frequent insomnia, anxiety, headache, and tachycardia. HR did not differ among conditions.

conclusionCombined CAF and CAP reduced 10-km completion time and increased post-exercise blood lactate and perceived vigor versus placebo. Session-RPE and heart rate did not differ among conditions; RPE differed only between CAF and CAP. CAF-containing conditions also produced more frequent transient adverse effects.

trial registrationBrazilian Registry of Clinical Trials, U1111-1333-3665, registered on February 2026.

Indexed as

Dietary supplementsFatiguePerformance-enhancing substancesPhysical exerciseSports nutrition

Identifiers

PMID42836870

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.