Evidence map›Paper›PMID 42836749›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2026

Longitudinal untargeted metabolomics of cognitive impairment in Parkinson's disease.

Yuyuan Lin, Yu Yu, Keren Zhang, Irish Del Rosario, Aline Duarte Folle, Elizabeth Rose Mayeda, Dean P Jones, Douglas I Walker, Jeff Bronstein, Adrienne M Keener and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Longitudinal untargeted metabolomics of cognitive impairment in Parkinson's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Yuyuan LinDepartment of Epidemiology, UCLA Fielding School of Public Health, Los Angeles, California, USA.ORCID https://orcid.org/0009-0006-7383-100X
Yu YuCenter for Health Policy Research, UCLA Fielding School of Public Health, Los Angeles, California, USA.
Keren ZhangDepartment of Epidemiology, UCLA Fielding School of Public Health, Los Angeles, California, USA.
Irish Del RosarioDepartment of Epidemiology, UCLA Fielding School of Public Health, Los Angeles, California, USA.
Aline Duarte FolleDepartment of Epidemiology, UCLA Fielding School of Public Health, Los Angeles, California, USA.
Elizabeth Rose MayedaDepartment of Epidemiology, UCLA Fielding School of Public Health, Los Angeles, California, USA.
Dean P JonesDivision of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.
Douglas I WalkerGangarosa Department of Environmental Health, Emory University School of Medicine, Atlanta, Georgia, USA.
Jeff BronsteinDepartment of Neurology, UCLA Fielding School of Public Health, Los Angeles, California, USA.
Adrienne M KeenerDepartment of Neurology, UCLA Fielding School of Public Health, Los Angeles, California, USA.
Kimberly C PaulDepartment of Neurology, UCLA Fielding School of Public Health, Los Angeles, California, USA.
Beate RitzDepartment of Epidemiology, UCLA Fielding School of Public Health, Los Angeles, California, USA.

Funding

Pilot Project ProgramP30ES019776 · NIEHS · EMORY UNIVERSITY · PI William Michael Caudle · 2013 to 2026
$22.6M
PARKINSON'S DISEASES SUSCEPTIBILITY GENES AND PESTICIDESR01ES010544 · NIEHS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI RITZ, BEATE R. · 2000 to 2015
$5.7M
Prenatal Exposure to Pesticide Mixtures and Childhood ADHDR00ES028743 · NIEHS · UNIVERSITY OF ARIZONA · PI FURLONG, MELISSA · 2020 to 2022
$747k
A Multi-omics approach to Environment and Depression in Parkinsons disease (MOOD-PD)R21ES032593 · NIEHS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI RITZ, BEATE R. · 2021 to 2022
$429k
Environmental exposure, DNA methylation, and Parkinson's diseaseR21ES024356 · NIEHS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HORVATH, STEVE, RITZ, BEATE R. · 2014 to 2015
$424k
National Institute of Environmental Health Sciences (NIEHS) 2R01ES010544National Institute of Environmental Health Sciences (NIEHS) 5P30ES019776National Institute of Environmental Health Sciences (NIEHS) R00ES028743National Institute of Environmental Health Sciences (NIEHS) R21ES024356National Institute of Environmental Health Sciences (NIEHS) R21ES032593NIA NIH HHS K01AG07204401NIEHS NIH HHS P30 ES019776NIEHS NIH HHS R00 ES028743NIEHS NIH HHS R01 ES010544NIEHS NIH HHS R21 ES024356NIEHS NIH HHS R21 ES032593U.S. Department of Defense (DoD) HT94252310415
6 · The paper itself

Abstract

introductionCognitive impairment is a common non-motor symptom of Parkinson's disease (PD), yet the mechanism remains unclear.

methodsLongitudinal serum samples from PD patients in a community-based case-control study were profiled, with cognition assessed by the Mini-Mental State Examination at baseline and follow-up. We performed three metabolome-wide association studies: a baseline cross-sectional analysis (n = 632), a time-to-event analysis (n = 412), and a repeated measures analysis (n = 265), followed by "Mummichog" pathway analysis.

resultsOf the 4762 metabolomic features, four reached statistical significance in the baseline analysis, 22 in the time-to-event analysis, and none in the repeated measures analysis. Dysregulated pathways included purine metabolism, the pentose phosphate pathway, fatty acid pathways, and C21-steroid hormone biosynthesis and metabolism. DISCUSSION: Disruptions in core metabolic pathways may contribute to PD-related cognitive impairments. Disturbances in pentose and purine pathways may occur before clinical cognitive decline is observed, suggesting early metabolic markers.

Indexed as

Cognitive DysfunctionMetabolomeMetabolomicsParkinson DiseaseAgedCase-Control StudiesCross-Sectional StudiesFemaleHumansLongitudinal StudiesMaleMiddle Agedcognitive impairmentmetabolomicsParkinson's disease

Identifiers

PMID42836749
PMCPMC13640969

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.