ReviewImmunity, inflammation and disease2026
Tripartite Interplay of Epithelial, Immune, and Microbiota Dysregulation in Crohn's Disease: Mechanisms and Translational Strategies.
Review in Immunity, inflammation and disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
backgroundCrohn's disease (CD) is a multifactorial inflammatory bowel disease (IBD) characterized by impaired epithelial barrier integrity, excessive immune hyperactivation, and gut microbiota perturbations. Cumulative evidence supports the role of the intestinal epithelial barrier, immune system and gut microbiota in the progression of CD.
objectiveThis review constructs a mechanistic framework of the epithelial-immune-microbiota tripartite network in CD with a focus on positive‑feedback circuits sustaining persistent intestinal inflammation. KEY
findingsInterrelated pathological loops involving barrier injury, immune activation and microbial dysbiosis perpetuate chronic intestinal inflammation and provide a rationale for mechanism‑guided combinatorial therapeutic interventions.
conclusionsThis framework illuminates key pathogenic crosstalk that may be targeted to optimize future treatment regimens for CD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.