Evidence map›Paper›PMID 42836507›Full record

SynthesisTransboundary and emerging diseases2026

Brucellosis in Southeast Asia: A Systematic Review of Epidemiological Evidence, Surveillance Gaps, and cgMLST-Based Insights Into Genetic Relatedness.

Qiuju Yang, Xiaoan Cao, Linghui Yuan, Na Zhang, Zhenjun Li, Zhiguo Liu

Abstract readSystematic Review
In one paragraph

Synthesis in Transboundary and emerging diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Qiuju YangDepartment of Zoonosis Prevention and Control, Yunnan Provincial Key Laboratory for Natural Focal Disease Control and Prevention, Yunnan Institute of Endemic Disease Control and Prevention, Kunming, 650500, China.ORCID https://orcid.org/0000-0003-1036-1320
Xiaoan CaoVeterinary Clinical Service Center, State Key Laboratory of Animal Disease Control and Prevention, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, 730046, China, caas.cn.ORCID https://orcid.org/0000-0001-6064-1297
Linghui YuanBranch of Biosafety, National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention and Chinese Academy of Preventive Medicine, Beijing, 102206, China, chinacdc.cn.
Na ZhangBranch of Biosafety, National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention and Chinese Academy of Preventive Medicine, Beijing, 102206, China, chinacdc.cn.
Zhenjun LiBranch of Biosafety, National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention and Chinese Academy of Preventive Medicine, Beijing, 102206, China, chinacdc.cn.
Zhiguo LiuBranch of Biosafety, National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention and Chinese Academy of Preventive Medicine, Beijing, 102206, China, chinacdc.cn.ORCID https://orcid.org/0009-0006-6914-9825

Funding

National Key Research and Development Program of China 2025YFD1800102
6 · The paper itself

Abstract

Brucellosis is an important zoonosis affecting public health and livestock production in Southeast Asia, but its regional epidemiology remains incompletely characterized. In this study, PubMed, Embase, Web of Science, and Scopus were searched for primary studies from the 11 Southeast Asian countries that reported serological findings, molecular detection, bacterial isolation, or Brucella species identification in human or animal populations. Publicly available PubMLST records were also analyzed using the 1764-locus Brucella core-genome multilocus sequence typing scheme. Across the eligible studies, reported crude seropositivity proportions ranged from 0.72% to 5.40% in humans and from 0.24% to 8.83% in animals. Molecular evidence included PCR positivity rates of 3.36% in goat vaginal swabs from Thailand and 39.2% in a selected mixed-livestock population from Indonesia, together with the identification of Brucella melitensis, B. abortus, and B. suis in several Southeast Asian countries. These findings provide epidemiological evidence of brucellosis in several countries. cgMLST analysis of the 24 available profiles from Malaysia and Thailand revealed close genetic relatedness among several isolates. Malaysian and Thai B. melitensis isolates differed by fewer than 11 alleles within the main cluster and by 41-81 alleles relative to isolates from India and the United Kingdom. Two Thai B. abortus isolates differed at only one locus and by 68-150 alleles from isolates from Bangladesh, India, and Bolivia, whereas five Malaysian B. suis isolates differed by 7-78 alleles, indicating limited genetic diversity within the Malaysian cluster. Additional genomic and epidemiological data are needed to determine whether genetically similar isolates are epidemiologically linked. Brucellosis appears endemic in parts of Southeast Asia, but important gaps in published data remain. Integrated One Health surveillance is needed to improve regional risk assessment and control.

Indexed as

BrucellaBrucellosisAnimalsAsia, SoutheasternHumansMultilocus Sequence TypingZoonosesbrucellosiscgMLSTSoutheast Asiasurveillancesystematic review

Identifiers

PMID42836507
PMCPMC13640528

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.