ArticleChemistry & biodiversity2026
Cytotoxic Dihydroagarofuran Sesquiterpenoids Isolated From the Roots of Tripterygium wilfordii.
Ya-Lin Hu, Yi-Ping Xie, Jing-Yi Huang, Chong Wang, Jia-Li Huang, Wen-Jie Chen, Zhen Li, Zuo-Dong Qin
Abstract read
In one paragraphArticle in Chemistry & biodiversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
8 authors.
Ya-Lin HuHunan Engineering Technology Research Center for Comprehensive Development and Utilization of Biomass Resources, College of Chemistry and Bioengineering, Hunan Institute of Science and Engineering, Yongzhou, China.ORCID https://orcid.org/0009-0008-6533-1384 Yi-Ping XieHunan Engineering Technology Research Center for Comprehensive Development and Utilization of Biomass Resources, College of Chemistry and Bioengineering, Hunan Institute of Science and Engineering, Yongzhou, China.
Jing-Yi HuangHunan Engineering Technology Research Center for Comprehensive Development and Utilization of Biomass Resources, College of Chemistry and Bioengineering, Hunan Institute of Science and Engineering, Yongzhou, China.
Chong WangHunan Engineering Technology Research Center for Comprehensive Development and Utilization of Biomass Resources, College of Chemistry and Bioengineering, Hunan Institute of Science and Engineering, Yongzhou, China.
Jia-Li HuangHunan Engineering Technology Research Center for Comprehensive Development and Utilization of Biomass Resources, College of Chemistry and Bioengineering, Hunan Institute of Science and Engineering, Yongzhou, China.
Wen-Jie ChenHunan Engineering Technology Research Center for Comprehensive Development and Utilization of Biomass Resources, College of Chemistry and Bioengineering, Hunan Institute of Science and Engineering, Yongzhou, China.
Zhen LiAnalysis of Complex Effects of Proprietary Chinese Medicine, Hunan Provincial Key Laboratory, Yongzhou, China.
Zuo-Dong QinHunan Provincial Key Laboratory for Health Aquaculture and Product Processing in Dongting Lake Area, Hunan University of Arts and Science, Changde, China.
Funding
Central Guidance on Local Science and Technology Development Fund of Hunan Province 2025ZYC011National Innovation and Entrepreneurship Training Program for College Students S202310551010
6 · The paper itselfAbstract
Extraction of the roots of Tripterygium wilfordii afforded ten undescribed dihydro-β-agarofuran derivatives [tripterdines M-V (1-10)], including five sesquiterpene polyesters and five sesquiterpene pyridine alkaloids, along with three known analogues (11-13). Through HRESIMS, spectroscopic analysis (UV, IR, ECD, and 1D/2D NMR), x‑ray crystallography, CD exciton chirality method, and ECD calculations, the structures of these undescribed compounds were elucidated. Four human cancer cell lines (SK-MEL-2, HCC1806, HUH-7, and PANC-1) and one human normal cell line (MRC-5) were used to screen all compounds for in vitro cytotoxicity via the CCK-8 method. Among the tested cell lines, SK‑MEL‑2 was the most sensitive toward undescribed compounds 2, 3, and 5, giving IC
Indexed as
Antineoplastic Agents, PhytogenicPlant RootsSesquiterpenesTripterygiumCell Line, TumorCell ProliferationCell SurvivalCrystallography, X-RayDose-Response Relationship, DrugDrug Screening Assays, AntitumorHumansModels, MolecularMolecular ConformationMolecular StructureStructure-Activity RelationshipAntineoplastic Agents, PhytogenicdihydroagarofuranSesquiterpenescytotoxicitydihydroagarofuran sesquiterpenoidsspectroscopic analysisstructural identificationTripterygium wilfordii
Identifiers
PMID42836456
PMCPMC13640043
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