Evidence map›Paper›PMID 42836338›Full record

ArticleBiomaterials science2026

Impact of the physico-chemical properties of surface-initiated polymer brushes on siRNA binding and transfection efficiency.

Carlos E Neri-Cruz, Davide Carta, Julien E Gautrot

Abstract read
In one paragraph

Article in Biomaterials science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Carlos E Neri-CruzSchool of Engineering and Materials Science, Queen Mary University of London, Mile End Road, London E1 4NS, UK. j.gautrot@qmul.ac.uk.ORCID http://orcid.org/0009-0000-0233-8628
Davide CartaSchool of Engineering and Materials Science, Queen Mary University of London, Mile End Road, London E1 4NS, UK. j.gautrot@qmul.ac.uk.
Julien E GautrotSchool of Engineering and Materials Science, Queen Mary University of London, Mile End Road, London E1 4NS, UK. j.gautrot@qmul.ac.uk.ORCID http://orcid.org/0000-0002-1614-2578

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Rational design of polycationic gene delivery vectors requires understanding how polymer chemistry governs RNA complexation, cellular uptake, and intracellular release kinetics. Poly(dimethylaminoethyl methacrylate) brushes were found to display striking potential for the delivery of siRNA, with high knockdown efficiency and low cytotoxicity. However, the impact of the physico-chemistry of a broader range of polymer brushes on RNA delivery has not been explored. Using a library of 10 cationic polymer brushes spanning tertiary amine and quaternary ammonium chemistries, we reveal how hydrophobicity, p

Identifiers

PMID42836338
PMCPMC13639890

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.