Evidence map›Paper›PMID 42836249›Full record

ArticleJournal of systems chemistry2010

Beyond allostery: Catalytic regulation of a deoxyribozyme through an entropy-driven DNA amplifier.

Grace Eckhoff, Vlad Codrea, Andrew D Ellington, Xi Chen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of systems chemistry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Grace EckhoffInstitute for Cellular and Molecular Biology, University of Texas at Austin, Austin, Texas 78712, USA.
Vlad CodreaInstitute for Cellular and Molecular Biology, University of Texas at Austin, Austin, Texas 78712, USA.
Andrew D EllingtonInstitute for Cellular and Molecular Biology, University of Texas at Austin, Austin, Texas 78712, USA.
Xi ChenDepartment of Chemistry and Biochemistry, University of Texas at Austin, Austin, Texas 78712, USA.

Funding

Electrochemical arrays for the detection of small molecule drugsR01EB007689 · NIBIB · UNIVERSITY OF CALIFORNIA SANTA BARBARA · PI PLAXCO, KEVIN W · 2008 to 2011
$1.3M
Genetic circuits based on allosteric ribozymesR01GM077040 · NIGMS · UNIVERSITY OF TEXAS AT AUSTIN · PI ELLINGTON, ANDREW D · 2006 to 2010
$1.1M
NIBIB NIH HHS R01 EB007689NIGMS NIH HHS R01 GM077040
6 · The paper itself

Abstract

The programmability and replicability of RNA and DNA have respectively enabled the design and selection of a number of allosteric ribozymes and deoxyribozymes. These catalysts have been adapted to function as signal transducers in biosensors and biochemical reaction networks both

Identifiers

PMID42836249
PMCPMC13638220

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.