ArticleCureus2026
Concurrent Diabetic Muscle Infarction and JAK2 Exon 12-Positive Polycythemia Vera: A Rare Dual Diagnosis.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Diabetic muscle infarction (DMI) is an uncommon and frequently underrecognized microvascular complication of longstanding diabetes mellitus characterized by spontaneous ischemic necrosis of skeletal muscle. Polycythemia vera (PV) associated with JAK2 exon 12 mutations represents a rare subtype of myeloproliferative neoplasm that typically presents with isolated erythrocytosis and suppressed serum erythropoietin levels. The coexistence of these two uncommon disorders is exceptionally rare and may create significant diagnostic challenges because painful limb swelling can mimic thrombotic, infectious, inflammatory, or neoplastic conditions. We report the case of a 52-year-old man with poorly controlled type 2 diabetes mellitus who presented with a 3-week history of progressive atraumatic pain and swelling of the left thigh. Doppler ultrasonography excluded deep vein thrombosis and abscess formation, while magnetic resonance imaging demonstrated diffuse muscle edema, short tau inversion recovery (STIR) hyperintensity, and characteristic findings consistent with DMI. Laboratory investigations revealed marked erythrocytosis (hemoglobin 19.9 g/dL), thrombocytosis, and suppressed serum erythropoietin levels. Bone marrow examination demonstrated hypercellularity with erythroid predominance, and molecular testing identified a JAK2 exon 12 mutation, fulfilling contemporary diagnostic criteria for polycythemia vera. Conservative management of DMI together with therapeutic phlebotomy for PV resulted in progressive clinical improvement. This case highlights the importance of maintaining a broad differential diagnosis when evaluating painful limb swelling in patients with diabetes mellitus and persistent erythrocytosis. Recognition of coexisting disorders through careful integration of clinical assessment, imaging, and hematological investigation allows timely diagnosis, avoids unnecessary invasive procedures, and facilitates appropriate disease-specific management.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.