Evidence map›Paper›PMID 42836216›Full record

ArticleFrontiers in toxicology2026

Detection of cancer epigenetic alterations in a pilot cohort of workers exposed to TiO

Eleonora Loi, Loredana Moi, Francesca Floris, Antonietta Marongiu, Paolo Valera, Matteo Serra, Enrico Sanjust, Cesare Zavattari, Alessandro Tommasi, Giuseppe Prencipe and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in toxicology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Eleonora Loi *Department of Biomedical Sciences, Unit of Biology and Genetics, University of Cagliari, Cagliari, Italy.
Loredana Moi *Department of Biomedical Sciences, Unit of Biology and Genetics, University of Cagliari, Cagliari, Italy.
Francesca FlorisDepartment of Biomedical Sciences, Unit of Biology and Genetics, University of Cagliari, Cagliari, Italy.
Antonietta MarongiuDepartment of Biomedical Sciences, Unit of Biology and Genetics, University of Cagliari, Cagliari, Italy.
Paolo ValeraDepartment of Civil-Environmental Engineering and Architecture, University of Cagliari, Cagliari, Italy.
Matteo SerraDepartment of Civil-Environmental Engineering and Architecture, University of Cagliari, Cagliari, Italy.
Enrico SanjustDepartment of Biomedical Sciences, Unit of Biochemistry, University of Cagliari, Cagliari, Italy.
Cesare ZavattariDepartment of Computer Science, University of Pisa, Pisa, Italy.
Alessandro TommasiDepartment of Computer Science, University of Pisa, Pisa, Italy.
Giuseppe PrencipeDepartment of Computer Science, University of Pisa, Pisa, Italy.
Fabio BoccuniEpidemiology and Hygiene, Department of Occupational and Environmental Medicine, National Institute for Insurance against Accidents at Work, Rome, Italy.
Rocco GibilrasDepartment of Technological Innovations and Safety of Plants, Products and Anthropic Settlements, National Institute for Insurance against Accidents at Work, Monte Porzio Catone, Rome, Italy.
Maddalena PapacchiniDepartment of Technological Innovations and Safety of Plants, Products and Anthropic Settlements, National Institute for Insurance against Accidents at Work, Monte Porzio Catone, Rome, Italy.
Marco Di Basilio *Department of Technological Innovations and Safety of Plants, Products and Anthropic Settlements, National Institute for Insurance against Accidents at Work, Monte Porzio Catone, Rome, Italy.
Patrizia Zavattari *Department of Biomedical Sciences, Unit of Biology and Genetics, University of Cagliari, Cagliari, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: The extensive use of TiO Methods: Due to the possible entry route, by ingestion or by inhalation, of TiO Results: The obtained results showed that exposed workers displayed higher methylation compared to healthy controls approaching the methylation patterns of colorectal cancer patients, even more evident for workers of some job categories. Moreover, the methylation data would highlight the importance of personal protective equipment, as observed in workers using a gas mask exhibiting a negligible methylation value compared to the job category average methylation level. Discussion: This preliminary investigation suggests the harmful role of TiO

Indexed as

colorectal cancerDNA methylationGRIA4job categorieslung cancernanoparticlesoccupational exposureTiO2

Identifiers

PMID42836216
PMCPMC13638187

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.