Evidence map›Paper›PMID 42836179›Full record

ArticleRegenerative biomaterials2026

Niosome-mediated melatonin delivery via SilMA/GelMA microneedles promotes healing of sleep deprivation-aggravated oral ulcers.

Ying Xie, Qi Huang, Xinzhi Jiang, Kehao Liu, Kamoran Tuerhong, Chengji Shi, Renjie Tang, Xuehui Hu, Youchun Zhang, Xiang Li and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Regenerative biomaterials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Ying XieDepartment of Prosthodontics, The Affiliated Stomatological Hospital of Chongqing Medical-University, Chongqing 401147, China.
Qi HuangDepartment of Prosthodontics, The Affiliated Stomatological Hospital of Chongqing Medical-University, Chongqing 401147, China.
Xinzhi JiangDepartment of Prosthodontics, The Affiliated Stomatological Hospital of Chongqing Medical-University, Chongqing 401147, China.
Kehao LiuDepartment of Prosthodontics, The Affiliated Stomatological Hospital of Chongqing Medical-University, Chongqing 401147, China.
Kamoran TuerhongDepartment of Prosthodontics, The Affiliated Stomatological Hospital of Chongqing Medical-University, Chongqing 401147, China.
Chengji ShiDepartment of Prosthodontics, The Affiliated Stomatological Hospital of Chongqing Medical-University, Chongqing 401147, China.
Renjie TangDepartment of Prosthodontics, The Affiliated Stomatological Hospital of Chongqing Medical-University, Chongqing 401147, China.
Xuehui HuDepartment of Orthodontics, The Affiliated Stomatological Hospital of Chongqing Medical-University, Chongqing 401147, China.
Youchun ZhangDepartment of Prosthodontics, The Affiliated Stomatological Hospital of Chongqing Medical-University, Chongqing 401147, China.
Xiang LiDepartment of Prosthodontics, The Affiliated Stomatological Hospital of Chongqing Medical-University, Chongqing 401147, China.
Mingcong YangDepartment of Periodontology, The Affiliated Stomatological Hospital of Chongqing Medical-University, Chongqing 401147, China.
Yuting HeDepartment of Prosthodontics, The Affiliated Stomatological Hospital of Chongqing Medical-University, Chongqing 401147, China.
Haixia DangDepartment of Prosthodontics, The Affiliated Stomatological Hospital of Chongqing Medical-University, Chongqing 401147, China.
Ming WangDepartment of Prosthodontics, The Affiliated Stomatological Hospital of Chongqing Medical-University, Chongqing 401147, China.
Danfeng ShenDepartment of Prosthodontics, The Affiliated Stomatological Hospital of Chongqing Medical-University, Chongqing 401147, China.
Sheng YangDepartment of Prosthodontics, The Affiliated Stomatological Hospital of Chongqing Medical-University, Chongqing 401147, China.
Peng YuDepartment of Cariology and Endodontology, Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices. Beijing 100081, China.
Yuzhou LiDepartment of Prosthodontics, The Affiliated Stomatological Hospital of Chongqing Medical-University, Chongqing 401147, China.ORCID https://orcid.org/0000-0003-1768-1140

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sleep disturbance disrupts immune homeostasis and impairs oral mucosal healing, yet effective local immunomodulatory strategies remain limited. Here, we identify excessive neutrophil extracellular traps (NETs) as a key mediator linking sleep deprivation to delayed oral wound closure. NETs-associated proteases compromise epithelial barrier function and suppress repair cell migration. To address this, we developed a melatonin-loaded niosome-incorporated silk fibroin methacrylate (SilMA)/gelatin methacryloyl (GelMA) composite hydrogel microneedle (Nio-MT@S-G MN) for localized melatonin delivery and regulation of the NET-associated inflammatory microenvironment. Niosomes achieve efficient encapsulation and sustained melatonin release, while SilMA/GelMA microneedles enable transmucosal administration with favorable mechanical strength.

Indexed as

melatoninneutrophil extracellular trapsnoisomeoral ulcersleep deprivation

Identifiers

PMID42836179
PMCPMC13637851

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.