ArticleFrontiers in microbiology2026
Quantitative phage-host interaction profiling supports the design of a broadly active phage cocktail against multidrug-resistant
Article in Frontiers in microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Methods: Thirty-eight lytic phages were isolated from poultry farm samples, genomically characterized, and evaluated against 51 clinical poultry isolates using efficiency of plating as a quantitative measure of productive infectivity. Results: The complete phage collection achieved 94.12% cumulative strain coverage, while genomic relatedness showed only a moderate association with infectivity profiles, highlighting the need for functional screening. Computational optimization identified a six-phage cocktail, CKT6, which displayed broad Discussion: These findings support quantitative phage-host interaction profiling as a robust framework for reproducible and adaptive phage-cocktail design. Further validation under biofilm-associated, formulation-relevant and field-like poultry-production conditions will be required before practical application.
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