ArticleRSC advances2026
Multifunctional chito-oligosaccharide-and deferoxamine-modified GelMA-OHA hydrogel dressing with antibacterial, antioxidant, and pro-angiogenic activities for infected wound healing.
Na Zhou, Jie Huang, Mengmeng Cao, Xiaohan Zhang, Shujian Zhang, Wenxuan Zhang, Xinrui Luan, Xuancheng Wei, Zansheng Huang, Han Jin and 2 more
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In one paragraphArticle in RSC advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
12 authors.
Na ZhouHeilongjiang Provincial Key Laboratory of Hard Tissue Development and Regeneration, The Second Affiliated Hospital of Harbin Medical University Harbin Heilongjiang 150001 China zhangbin@hrbmu.edu.cn liying@hrbmu.edu.cn.
Jie HuangHeilongjiang Provincial Key Laboratory of Hard Tissue Development and Regeneration, The Second Affiliated Hospital of Harbin Medical University Harbin Heilongjiang 150001 China zhangbin@hrbmu.edu.cn liying@hrbmu.edu.cn.
Mengmeng CaoHeilongjiang Provincial Key Laboratory of Hard Tissue Development and Regeneration, The Second Affiliated Hospital of Harbin Medical University Harbin Heilongjiang 150001 China zhangbin@hrbmu.edu.cn liying@hrbmu.edu.cn.
Xiaohan ZhangHeilongjiang Provincial Key Laboratory of Hard Tissue Development and Regeneration, The Second Affiliated Hospital of Harbin Medical University Harbin Heilongjiang 150001 China zhangbin@hrbmu.edu.cn liying@hrbmu.edu.cn.
Wenxuan ZhangHeilongjiang Provincial Key Laboratory of Hard Tissue Development and Regeneration, The Second Affiliated Hospital of Harbin Medical University Harbin Heilongjiang 150001 China zhangbin@hrbmu.edu.cn liying@hrbmu.edu.cn.
Xinrui LuanHeilongjiang Provincial Key Laboratory of Hard Tissue Development and Regeneration, The Second Affiliated Hospital of Harbin Medical University Harbin Heilongjiang 150001 China zhangbin@hrbmu.edu.cn liying@hrbmu.edu.cn.
Xuancheng WeiHeilongjiang Provincial Key Laboratory of Hard Tissue Development and Regeneration, The Second Affiliated Hospital of Harbin Medical University Harbin Heilongjiang 150001 China zhangbin@hrbmu.edu.cn liying@hrbmu.edu.cn.
Zansheng HuangHeilongjiang Provincial Key Laboratory of Hard Tissue Development and Regeneration, The Second Affiliated Hospital of Harbin Medical University Harbin Heilongjiang 150001 China zhangbin@hrbmu.edu.cn liying@hrbmu.edu.cn.
Han JinHeilongjiang Provincial Key Laboratory of Hard Tissue Development and Regeneration, The Second Affiliated Hospital of Harbin Medical University Harbin Heilongjiang 150001 China zhangbin@hrbmu.edu.cn liying@hrbmu.edu.cn.ORCID https://orcid.org/0000-0002-6877-6433 Bin ZhangHeilongjiang Provincial Key Laboratory of Hard Tissue Development and Regeneration, The Second Affiliated Hospital of Harbin Medical University Harbin Heilongjiang 150001 China zhangbin@hrbmu.edu.cn liying@hrbmu.edu.cn.
Ying LiHeilongjiang Provincial Key Laboratory of Hard Tissue Development and Regeneration, The Second Affiliated Hospital of Harbin Medical University Harbin Heilongjiang 150001 China zhangbin@hrbmu.edu.cn liying@hrbmu.edu.cn.ORCID https://orcid.org/0000-0001-5924-8316 Funding
No grant is acknowledged in the PubMed record.
6 · The paper itselfAbstract
Infected wounds resist healing due to multidrug-resistant bacterial colonization and persistent inflammation, which render conventional antibiotic therapies largely ineffective. Consequently, non-antibiotic strategies that coordinate infection control with tissue regeneration are urgently required. We design a dual-crosslinked hydrogel composed of gelatin methacryloyl (GelMA) and oxidized hyaluronic acid (OHA), further functionalized with chitosan oligosaccharide (COS) and deferoxamine (DFO), yielding the multifunctional GOCD hydrogel. Dynamic Schiff base linkages confer controlled release of COS and DFO, enabling coordinated antibacterial, antioxidant, and pro-regenerative activities. Experiments show that the GOCD hydrogel achieves an antibacterial rate of 88.03% against methicillin-resistant
Identifiers
PMID42836175
PMCPMC13637681
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