Evidence map›Paper›PMID 42836088›Full record

ArticleProteoglycan research2025

Hyaluronan Accumulates in Inflamed Lymph Nodes and Promotes B-Cell Activation.

Zhiwei Li, Nadine Nagy, Gernot Kaber, Payton L Marshall, Naomi L Haddock, Everett Meyer, Robert R Vernon, Manish J Butte, Ovijit Chaudhuri, Thomas N Wight and 1 more

Abstract read
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In one paragraph

Article in Proteoglycan research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Zhiwei LiDepartment of Medicine, Division of Infectious Diseases and Geographic Medicine, Stanford University, Stanford, California, USA.ORCID 0000-0002-9375-7138
Nadine NagyDepartment of Medicine, Division of Blood and Marrow Transplantation & Cellular Therapy, Stanford University, Stanford, California, USA.
Gernot KaberDepartment of Medicine, Division of Oncology, Stanford University, Stanford, California, USA.
Payton L MarshallDepartment of Medicine, Division of Infectious Diseases and Geographic Medicine, Stanford University, Stanford, California, USA.
Naomi L HaddockDepartment of Medicine, Division of Infectious Diseases and Geographic Medicine, Stanford University, Stanford, California, USA.
Everett MeyerDepartment of Medicine, Division of Blood and Marrow Transplantation, Stanford University, Stanford, California, USA.
Robert R VernonMatrix Biology Program, Center for Fundamental Immunology, Benaroya Research Institute, Seattle, Washington, USA.
Manish J ButteDepartments of Pediatrics and Microbiology, Immunology, and Molecular Genetics, Division of Immunology, Allergy, and Rheumatology, University of California Los Angeles, Los Angeles, California, USA.
Ovijit ChaudhuriDepartment of Mechanical Engineering, Stanford University, Stanford, California, USA.
Thomas N WightMatrix Biology Program, Center for Fundamental Immunology, Benaroya Research Institute, Seattle, Washington, USA.
Paul L BollykyDepartment of Medicine, Division of Infectious Diseases and Geographic Medicine, Stanford University, Stanford, California, USA.

Funding

Tissue Cytokine Sequestration and Immune Regulation in AutoimmunityU01AI101984 · NIAID · STANFORD UNIVERSITY · PI BOLLYKY, PAUL L · 2012 to 2021
$5.0M
Lymph Node Extracellular Matrix in Antigen Presentation and Immune RegulationR01DK096087 · NIDDK · STANFORD UNIVERSITY · PI BOLLYKY, PAUL L · 2012 to 2021
$3.4M
ECM Costimulation of Immunoregulatory Pathways in Airway InflammationR01HL113294 · NHLBI · STANFORD UNIVERSITY · PI BOLLYKY, PAUL L · 2012 to 2016
$2.0M
The Role of Hyaluronan and CD44 in the Pathogenesis of Type 2 DiabetesR01DK116782 · NIDDK · STANFORD UNIVERSITY · PI BOLLYKY, PAUL L · 2020 to 2023
$1.6M
The Development of 4-methylumbelliferone Pro-drugs to Prevent Autoimmune DiabetesR01DK114174 · NIDDK · STANFORD UNIVERSITY · PI BOLLYKY, PAUL L · 2018 to 2020
$1.3M
NHLBI NIH HHS R01 HL113294NIAID NIH HHS U01 AI101984NIDDK NIH HHS R01 DK096087NIDDK NIH HHS R01 DK114174NIDDK NIH HHS R01 DK116782
6 · The paper itself

Abstract

The extracellular matrix component hyaluronan (HA) plays important roles in inflammation and immune regulation. However, its involvement in lymphoid tissue during autoreactive processes remains poorly understood. Here, using the DORmO mouse model of autoimmune diabetes, we demonstrate that HA progressively accumulates in lymph nodes and splenic germinal centers during disease development. This accumulation is accompanied by a shift from high to low molecular mass HA fragments. Through immunofluorescence microscopy, we observed extensive colocalization between HA deposits and B cells in germinal centers. Inhibition of HA synthesis using 4-methylumbelliferone (4-MU) increased lymph node stiffness. Treatment with 4-MU decreased immunoglobulin production and reduced B cell activation and differentiation into plasmablasts following immunization. These findings reveal a previously unrecognized role for HA in regulating B cell responses within lymphoid tissues during autoimmune reactions and suggest that targeting HA synthesis may represent a novel therapeutic strategy for conditions involving dysregulated B cell responses.

Indexed as

4-methylumbelliferoneautoimmune diabetesB cellshyaluronanlymph nodes

Identifiers

PMID42836088
PMCPMC13637525

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.