Electrospun poly(vinyl alcohol) nanofibers loaded with quaternary ammonium compounds for localized eradication of periodontal biofilms.

Ting Chen, Nicola Kelly, Pedro Leonidas Oseliero Filho, Megan Carr, Alexander Ciupa, Jenny Aveyard, Raechelle A D'Sa

Abstract read

In one paragraph

Article in Materials advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ting ChenSchool of Engineering, University of Liverpool, Brownlow Hill Liverpool L69 3GH UK r.dsa@liverpool.ac.uk.ORCID https://orcid.org/0000-0001-9570-7946

Nicola KellySchool of Engineering, University of Liverpool, Brownlow Hill Liverpool L69 3GH UK r.dsa@liverpool.ac.uk.

Pedro Leonidas Oseliero FilhoMaterials Innovation Factory, University of Liverpool, Oxford Street Liverpool L7 3NY UK.

Megan CarrMaterials Innovation Factory, University of Liverpool, Oxford Street Liverpool L7 3NY UK.

Alexander CiupaMaterials Innovation Factory, University of Liverpool, Oxford Street Liverpool L7 3NY UK.

Jenny AveyardSchool of Engineering, University of Liverpool, Brownlow Hill Liverpool L69 3GH UK r.dsa@liverpool.ac.uk.

Raechelle A D'SaSchool of Engineering, University of Liverpool, Brownlow Hill Liverpool L69 3GH UK r.dsa@liverpool.ac.uk.ORCID https://orcid.org/0000-0003-2651-8783

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Periodontitis is driven by polymicrobial biofilms and remains difficult to treat using systemic antibiotics, which fail to achieve therapeutic concentrations within periodontal pockets. In this study, we report on the fabrication of electrospun poly(vinyl alcohol) (PVA) nanofibers incorporating quaternary ammonium compounds (QACs)-specifically benzyltriethylammonium chloride (BTEAC) and benzyldimethyldodecylammonium chloride (BDMDAC) as localized antimicrobial platforms. Electrospinning parameters were optimized to achieve high drug loading and reproducible fiber morphologies. Incorporation of QACs reduced their porosity and surface area, while thermal stability increased because of enhanced intermolecular interactions. The nanofibers exhibited high wettability and sufficient integrity for specimen handling for oral applications, and the structures remained stable in artificial saliva. Both formulations demonstrated rapid

Identifiers

PMID42836067

DOI10.1039/d6ma00633g

PMCPMC13637459

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.