Evidence map›Paper›PMID 42836018›Full record

Reviewnpj women's health2026

Parabens and estrogen-mediated cancers: unraveling coincidence, co-occurrence, and causality.

Zehra Esra Ilhan, Andrea Marchetto, Georgia Lorentzen, Paweł Łaniewski, Leslie V Farland, Melissa M Herbst-Kralovetz

Abstract readReview
In one paragraph

Review in npj women's health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Zehra Esra IlhanUniversité Paris-Saclay, INRAE, AgroParisTech, Micalis Institute, Jouy-en-Josas, France.ORCID 0000-0002-3387-9424
Andrea MarchettoUniversité Paris-Saclay, INRAE, AgroParisTech, Micalis Institute, Jouy-en-Josas, France.
Georgia LorentzenDepartment of Obstetrics and Gynecology, College of Medicine-Phoenix, University of Arizona, Phoenix, AZ USA.
Paweł ŁaniewskiDepartment of Basic Medical Sciences, College of Medicine-Phoenix, University of Arizona, Phoenix, AZ USA.
Leslie V FarlandDepartment of Epidemiology and Biostatistics, Mel and Enid Zuckerman College of Public Health, Department of Obstetrics and Gynecology, College of Medicine -Tucson, University of Arizona, Tucson, AZ USA.
Melissa M Herbst-KralovetzDepartment of Obstetrics and Gynecology, College of Medicine-Phoenix, University of Arizona, Phoenix, AZ USA.

Funding

Uranium as an Environmental Risk Factor for Cancer Among the NavajoU54CA143924 · NCI · UNIVERSITY OF ARIZONA · PI Melissa Marie Herbst-Kralovetz, JUANITA L. MERCHANT · 2009 to 2026
$26.7M
NCI NIH HHS U54 CA143924
6 · The paper itself

Abstract

Paraben esters are endocrine disruptors linked to breast cancer, yet their role in other estrogen-mediated cancers remains limited. Preclinical evidence suggests that parabens accumulate in tissues and may promote carcinogenesis, while clinical data indicate widespread exposure. Our re-analysis of cervicovaginal metabolomes revealed elevated paraben metabolites in endometrial and cervical cancer patients compared with controls. Overall, longitudinal studies considering intrinsic and environmental factors are needed in assessing paraben-related cancer risk.

Indexed as

CancerOncology

Identifiers

PMID42836018
PMCPMC13637036

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.