ReviewRSC advances2026
Next-generation smart polymeric hydrogels for chronic wound management: integrating antimicrobial, immunomodulatory and regenerative strategies.
Review in RSC advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Wound healing is a tightly orchestrated sequence of hemostatic, inflammatory, proliferative, and remodeling events, yet chronic wounds arise when this cascade is dysregulated by persistent infection, excessive oxidative stress, and biofilm formation. Such pathological conditions particularly in diabetic and vascular-compromised patients sustain inflammatory signaling, impair angiogenesis, and disrupt extracellular matrix (ECM) turnover. In this study, we comprehensively evaluated these pathological barriers while presenting an integrated overview of recent advances in multifunctional smart hydrogels engineered to overcome them. Rather than treating antimicrobial, immunomodulatory and regenerative functions as independent therapeutic categories, this review established a microenvironment material function translation framework emphasizing their temporal and spatial coordination. We further critically examined dynamic network chemistries, nanocomposite and multicomponent architectures, advanced 3D/4D fabrication, AI-assisted formulation and wound monitoring, preclinical model limitations, manufacturing scalability and regulatory barriers. By distinguishing promising proof-of-concept strategies from technologies approaching clinical translation, this review identifies design principles for safer, more reproducible and clinically relevant smart hydrogel systems. Finally, we addressed translational barriers including scalability, regulatory classification, and long-term biocompatibility and outline future directions for AI-integrated, patient-specific hydrogel systems. Collectively, this study provides a comprehensive technical assessment of next-generation polymeric hydrogels as precision platforms for advanced wound management.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.