ArticleScience in One Health2026
Genome-wide host-associated population structure of
Article in Science in One Health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
11 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Background: Scabies, caused by the mite Methods: We generated whole-genome sequence data for 106 Results: We identified 1,568,031 filter-passing nuclear variants, including 698,136 single-nucleotide polymorphisms; sample-level heterozygosity estimates ranged from 0.27% to 11%. ADMIXTURE, principal component and phylogenetic analyses supported seven ancestry clusters broadly corresponding to host-associated groups, with pairwise fixation-index estimates ranging from 0.22 to 0.92. Multi-metric analysis identified 1600 candidate selection blocks - eight hard-sweep, 486 soft-sweep and 1106 ancient-adaptation blocks - and six conserved low-diversity blocks. Variable genes showed nominal enrichment for DNA repair, cell adhesion and signalling, whereas invariable genes showed nominal enrichment for ribosomal function, oxidative phosphorylation and mitochondrial processes. Conclusions: This expanded multi-host analysis reinforces and extends evidence that host association is a prominent correlate of genome-wide population structure in
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