Fluorination of amino-quinones enhances anti-

Zhenhao Zhong, Renata G Almeida, Victor F S Ramos, Andrew J Lacey, Rubem F S Menna-Barreto, Guilherme A M Jardim, Eufrânio N da Silva Júnior, Alastair J J Lennox

Abstract read

PubMed Full text at PMC Publisher

In one paragraph

Article in RSC medicinal chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Zhenhao ZhongSchool of Chemistry, University of Bristol Cantock's Close Bristol BS8 1TS UK a.lennox@bristol.ac.uk.ORCID https://orcid.org/0000-0002-8019-2166

Renata G AlmeidaInstituto de Ciências Exatas, Departamento de Química, Universidade Federal de Minas Gerais CEP 31270-901 Belo Horizonte MG Brazil eufranio@ufmg.br.ORCID https://orcid.org/0000-0003-2896-0487

Victor F S RamosLaboratório de Biologia Celular, IOC, FIOCRUZ Rio de Janeiro RJ 21045-900 Brazil.ORCID https://orcid.org/0009-0005-6208-1621

Andrew J LaceySchool of Chemistry, University of Bristol Cantock's Close Bristol BS8 1TS UK a.lennox@bristol.ac.uk.ORCID https://orcid.org/0009-0008-7403-1471

Rubem F S Menna-BarretoLaboratório de Biologia Celular, IOC, FIOCRUZ Rio de Janeiro RJ 21045-900 Brazil.ORCID https://orcid.org/0000-0002-1352-0641

Guilherme A M JardimInstituto de Ciências Exatas, Departamento de Química, Universidade Federal de Minas Gerais CEP 31270-901 Belo Horizonte MG Brazil eufranio@ufmg.br.ORCID https://orcid.org/0000-0002-9882-3085

Eufrânio N da Silva JúniorInstituto de Ciências Exatas, Departamento de Química, Universidade Federal de Minas Gerais CEP 31270-901 Belo Horizonte MG Brazil eufranio@ufmg.br.ORCID https://orcid.org/0000-0003-1281-5453

Alastair J J LennoxSchool of Chemistry, University of Bristol Cantock's Close Bristol BS8 1TS UK a.lennox@bristol.ac.uk.ORCID https://orcid.org/0000-0003-2019-7421

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Quinones are well-established antiparasitic agents. Despite the widespread use of fluorine to modulate biological activity and physicochemical properties in drug design, its systematic incorporation into quinoidal frameworks remains underexplored. Here, we report a mild and operationally simple direct electrophilic fluorination of a wide scope of amino-substituted 1,4-naphthoquinones. The fluorinated quinones were evaluated

Identifiers

PMID42835953

DOI10.1039/d6md00631k

PMCPMC13636235

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.