ReviewFrontiers in microbiology2026
Gut microbiota-derived indole metabolites in colorectal cancer: potential links to PI3K/AKT signaling pathway.
Review in Frontiers in microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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5 authors.
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Abstract
Gut inflammation associated with colorectal cancer (CRC) is closely linked to gut microbiota dysbiosis and altered microbial metabolites that disrupt intestinal homeostasis. Among these metabolites, indole derivatives produced through microbial tryptophan metabolism have emerged as important regulators of colon health. Recent evidence suggests that indole derivatives can influence gut barrier integrity, colon inflammation, and CRC progression. In this mini-review, we summarize current evidence regarding the role of indole derivatives in gut barrier regulation and CRC development. We also discuss their potential relationship with signaling pathways implicated in CRC progression, particularly the PI3K/AKT pathway, which may offer new perspectives on improving colon health and preventing inflammation-associated CRC.
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