ReviewClinical, cosmetic and investigational dermatology2026
Integrative Aesthetics: Shaping the Emerging Frontier of Modern Aesthetic Medicine.
Review in Clinical, cosmetic and investigational dermatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aesthetic medicine is moving beyond an appearance-centered focus toward approaches that also prioritize long-term skin and underlying tissue health. Skin health and systemic health are now widely recognized as closely interconnected through shared mechanisms of aging biology, yet a practical clinical construct for translating this understanding into aesthetic practice remains to be established. In this conceptual review article, we propose Integrative Aesthetics (IA) as a clinically grounded framework that positions aesthetic and systemic health improvement as coequal, mutually reinforcing clinical goals, organized through 2 interconnected layers: local tissue optimization and systemic health optimization. These aims are operationalized through 3 synergistic pillars: i) conventional aesthetic interventions, ii) regenerative therapies, and iii) functional medicine. Conventional aesthetic interventions provide direct structural and surface-level correction; regenerative therapies support tissue quality by modulating the local microenvironment and repair pathways; and functional medicine addresses modifiable upstream determinants of tissue responsiveness, including nutrition, mitochondrial function, endocrine status, lifestyle, and broader biological aging processes. By integrating local and systemic strategies, IA proposes a mutually reinforcing model in which improved systemic health enhances procedural readiness, recovery, and remodeling, while improved skin and supporting tissue health, and the visible aesthetic benefits they produce, may support broader patient engagement in long-term health optimization. IA therefore offers a practical framework for reorienting aesthetic medicine toward a more whole-person, multidisciplinary, and health-focused model of care.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.