Evidence map›Paper›PMID 42835727›Full record

ArticleBlood red cells & iron2026

Brain MRI and cognitive outcomes in adults with sickle cell disease treated with crizanlizumab.

Yan Wang, Slim Fellah, Kristina Rankine, Martin N Reis, Serguei Astafiev, Lauren Brewer, Morey Blinder, Allison A King, Yasheng Chen, Sheng-Kwei Song and 2 more

Abstract read
In one paragraph

Article in Blood red cells & iron, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Yan WangDepartment of Neurology, Washington University School of Medicine, St. Louis, MO.ORCID 0000-0002-3750-0311
Slim FellahDepartment of Neurology, Washington University School of Medicine, St. Louis, MO.
Kristina RankineDepartment of Neurology, Columbia University Irving Medical Center, New York, NY.ORCID 0009-0007-2413-4168
Martin N ReisMallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO.
Serguei AstafievMallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO.ORCID 0000-0003-3736-7095
Lauren BrewerDepartment of Medicine, Division of Hematology, Washington University School of Medicine, St. Louis, MO.
Morey BlinderDepartment of Medicine, Division of Hematology, Washington University School of Medicine, St. Louis, MO.
Allison A KingDepartment of Pediatrics, Washington University School of Medicine, St. Louis, MO.ORCID 0000-0002-1951-6176
Yasheng ChenDepartment of Neurology, Washington University School of Medicine, St. Louis, MO.ORCID 0000-0002-1133-452X
Sheng-Kwei SongMallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO.ORCID 0000-0003-1050-7449
Hongyu AnDepartment of Neurology, Washington University School of Medicine, St. Louis, MO.ORCID 0000-0001-6459-2269
Andria L FordDepartment of Neurology, Washington University School of Medicine, St. Louis, MO.ORCID 0000-0003-0605-8943

Funding

MR-Derived Cerebral Oxygen Metabolism underlying Ischemic Vulnerability in Sickle Cell DiseaseR01HL129241 · NHLBI · WASHINGTON UNIVERSITY · PI Hongyu An, Robert A Campbell · 2015 to 2026
$6.6M
MR measured regional hypoxia as an early biomarker in cerebral small vessel diseaseRF1NS116565 · NINDS · WASHINGTON UNIVERSITY · PI AN, HONGYU, FORD, ANDRIA LEE · 2020 to 2020
$3.4M
The Role of Blood-Brain Barrier Disruption on Ischemic Brain Injury and Cognitive Impairment in Sickle Cell DiseaseK23HL173831 · NHLBI · WASHINGTON UNIVERSITY · PI Yan Wang · 2025 to 2026
$393k
NHLBI NIH HHS K23 HL173831NHLBI NIH HHS R01 HL129241NINDS NIH HHS RF1 NS116565
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Identifiers

PMID42835727
PMCPMC13637343

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.