Biomolecule-polymer conjugates synthesized by a combination of organometallic bioconjugation and atom transfer radical polymerization.

Hayden R Montgomery, Tong Zhang, Grace E Kunkel, Magdalena F Polite, Jeonghun Lee, Marco S Messina, Alexander M Spokoyny, Heather D Maynard

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Article in Polymer chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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8 authors.

Hayden R MontgomeryDepartment of Chemistry and Biochemistry, University of California, Los Angeles 607 Charles E. Young Drive East Los Angeles California 90095-1569 USA hmaynard@ucla.edu.ORCID https://orcid.org/0000-0002-6750-0830

Tong ZhangDepartment of Chemistry and Biochemistry, University of California, Los Angeles 607 Charles E. Young Drive East Los Angeles California 90095-1569 USA hmaynard@ucla.edu.

Grace E KunkelDepartment of Chemistry and Biochemistry, University of California, Los Angeles 607 Charles E. Young Drive East Los Angeles California 90095-1569 USA hmaynard@ucla.edu.ORCID https://orcid.org/0000-0001-8137-7552

Magdalena F PoliteDepartment of Chemistry and Biochemistry, University of California, Los Angeles 607 Charles E. Young Drive East Los Angeles California 90095-1569 USA hmaynard@ucla.edu.ORCID https://orcid.org/0009-0000-7172-301X

Jeonghun LeeDepartment of Chemistry and Biochemistry, University of California, Los Angeles 607 Charles E. Young Drive East Los Angeles California 90095-1569 USA hmaynard@ucla.edu.ORCID https://orcid.org/0000-0002-9996-0110

Marco S MessinaDepartment of Chemistry and Biochemistry, University of Delaware, 102 Brown Laboratory Newark DE 19716 USA.ORCID https://orcid.org/0000-0003-2827-118X

Alexander M SpokoynyDepartment of Chemistry and Biochemistry, University of California, Los Angeles 607 Charles E. Young Drive East Los Angeles California 90095-1569 USA hmaynard@ucla.edu.ORCID https://orcid.org/0000-0002-5683-6240

Heather D MaynardDepartment of Chemistry and Biochemistry, University of California, Los Angeles 607 Charles E. Young Drive East Los Angeles California 90095-1569 USA hmaynard@ucla.edu.ORCID https://orcid.org/0000-0003-3692-6289

Funding

Inorganic Chemistry Tools for Bioconjugation, Recognition and ImagingR35GM124746 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Alexander Michael Spokoyny · 2017 to 2026

$4.0M

NIGMS NIH HHS R35 GM124746

6 · The paper itself

Abstract

Organometallic Au(iii) cysteine arylation strategies have recently been employed for efficient and selective conjugation to proteins and peptides. In this work, atom transfer radical polymerization (ATRP) was utilized to synthesize iodophenyl end-functionalized poly(polyethylene glycol methacrylate) (pPEGMA), poly(hydroxyethyl methacrylate) (pHEMA) and poly(2-(dimethylamino)ethyl methacrylate) (pDMAEMA), which were subjected to MeDalPhos-Au(i)Cl to form Au(iii) polymer reagents. The Au(iii)-pPEGMA was reacted with T4-lysozyme (T4L) containing a free thiol to form a T4L-pPEGMA conjugate. In a complementary approach, an Au(iii) ATRP initiator was synthesized for subsequent conjugation to a peptide and T4L to form biomacroinitators. These peptide and protein macroinitiators were then subjected to polymerization conditions to form pDMAEMA conjugates

Identifiers

PMID42835709

DOI10.1039/d6py00714g

PMCPMC13637460

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