ArticleJournal of translational autoimmunity2026
Age-dependent association of thyroid peroxidase antibodies with incident cardiovascular disease events: Insights from a longitudinal cohort study.
Article in Journal of translational autoimmunity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: The relationship between thyroid autoimmunity and cardiovascular disease (CVD) is controversial, and age-specific effects are not well characterized. We examined associations between thyroid peroxidase antibodies (TPOAb) status and incident CVD. Methods: In this prospective population-based cohort, 4825 adults aged Results: A total of 4825 participants (56.5% female and mean age of 39.7 ± 14.0 years) were included. During follow-up, 576 incident CVD events occurred. In the overall population, TPOAb was not associated with CVD risk (adjusted HR per 1-SD increase: 1.04, 95%CI 0.95-1.13). The primary continuous-age spline analysis demonstrated significant effect modification by age (global interaction Conclusions: Thyroid autoimmunity was not associated with incident CVD in the overall cohort but demonstrated a significant age-dependent association. Exploratory analyses suggested increased risk among participants aged <40 years. These hypothesis-generating findings identify age as a potentially important modifier of the thyroid autoimmunity-CVD association and warrant validation in independent cohorts.
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