ArticleERJ open research2026
Initiation of inhaled antibiotic therapy in chronic airway diseases: the REPAIR registry.
Article in ERJ open research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
22 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Inhaled antibiotic therapy (IAT) is increasingly used in chronic airway diseases beyond cystic fibrosis. However, the clinical context and determinants driving IAT initiation in routine practice remain insufficiently characterised. Methods: REPAIR is a prospective, multicentre national registry including adult patients with chronic airway diseases at the moment of IAT initiation. This cross-sectional baseline analysis describes clinical, microbiological and phenotypic characteristics, as well as prescribing patterns. Chronic bronchial infection (CBI) was defined as ≥3 isolations of the same potentially pathogenic microorganism within 12 months. Results: A total of 411 patients were included (mean age 67.9±13.8 years; 57.2% women). Patients experienced 2.6±2.2 exacerbations in the previous year and 40.4% required hospitalisation. Conclusions: In routine clinical practice, initiation of IAT in chronic airway diseases appears predominantly microbiology-driven. Although most patients start treatment under stable conditions, a substantial proportion initiate IAT during exacerbation or early convalescence, indicating that clinical instability remains an important trigger for treatment initiation in real-world practice.
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