Evidence map›Paper›PMID 42835543›Full record

ArticleMaterials today. Bio2026

Cartilage-targeting engineered probiotic bacterial extracellular vesicles treat osteoarthritis through modulation of matrix homeostasis.

Luyu Niu, Wanzhuo Chen, Tong Liu, Xiaoyi Liang, Peiran Song, Han Liu, Teng Su, Xiao Chen, Zhongtang Liu, Yingying Jing and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Luyu NiuDepartment of Orthopedics, Changhai Hospital, Naval Medical University, Shanghai, China.
Wanzhuo ChenInstitute of Translational Medicine, Shanghai University, Shanghai, China.
Tong LiuMedEng-X Insititutes, Shanghai University, Shanghai, China.
Xiaoyi LiangMedEng-X Insititutes, Shanghai University, Shanghai, China.
Peiran SongInstitute of Translational Medicine, Shanghai University, Shanghai, China.
Han LiuInstitute of Translational Medicine, Shanghai University, Shanghai, China.
Teng SuInstitute of Translational Medicine, Shanghai University, Shanghai, China.
Xiao ChenDepartment of Orthopedics, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Zhongtang LiuDepartment of Orthopedics, Changhai Hospital, Naval Medical University, Shanghai, China.
Yingying JingInstitute of Translational Medicine, Shanghai University, Shanghai, China.
Jin CuiDepartment of Orthopedics, Changhai Hospital, Naval Medical University, Shanghai, China.
Jiacan SuDepartment of Orthopedics, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Reversing extracellular matrix (ECM) metabolic dysregulation to facilitate cartilage repair represents a key therapeutic strategy for osteoarthritis (OA) treatment. Owing to the avascular nature of joint structures, intra-articular injection is a commonly used clinical administration route. However, the current drug retention time is insufficient to effectively reverse OA progression. In this study, we demonstrated that natural bacterial extracellular vesicles (BEVs) are capable of repairing cartilage damage. We modified

Indexed as

Bacterial extracellular vesicleExtracellular matrixIntra-articular drug deliveryOsteoarthritisTargeted therapy

Identifiers

PMID42835543
PMCPMC13635493

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.