Evidence map›Paper›PMID 42835465›Full record

ReviewFrontiers in cellular and infection microbiology2026

Exploring the role of infectious pathogens in Alzheimer's disease neuroinflammation.

Salvatore Vaiasicca, Gianmarco Mangiaterra, Barbara Citterio, Giorgia Piccioni, Fiorenza Orlando, Belinda Giorgetti, Laura Cianfruglia, Robertina Giacconi, Stefania Fumarola, Maurizio Cardelli and 4 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in cellular and infection microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Salvatore Vaiasicca *Center of Biogerontology, IRCCS INRCA, Ancona, Italy.
Gianmarco Mangiaterra *Department of Biomolecular Sciences, University of Urbino Carlo Bo, Biotechnology section, Fano, Italy.
Barbara CitterioDepartment of Biomolecular Sciences, University of Urbino Carlo Bo, Biotechnology section, Fano, Italy.
Giorgia PiccioniDepartment of Biomolecular Sciences, University of Urbino Carlo Bo, Biotechnology section, Fano, Italy.
Fiorenza OrlandoExperimental Animal Models for Aging Unit, Scientific Technological Area, IRCCS INRCA, Falconara, Marittima, Italy.
Belinda GiorgettiCenter of Biogerontology, IRCCS INRCA, Ancona, Italy.
Laura CianfrugliaCenter of Biogerontology, IRCCS INRCA, Ancona, Italy.
Robertina GiacconiCenter of Biogerontology, IRCCS INRCA, Ancona, Italy.
Stefania FumarolaCenter of Biogerontology, IRCCS INRCA, Ancona, Italy.
Maurizio CardelliCenter of Biogerontology, IRCCS INRCA, Ancona, Italy.
Leonardo BiscettiNeurology Unit, IRCCS INRCA, Ancona, Italy.
Paolo PelliccioniOphthalmology Department, AST Pesaro Urbino, Pesaro, Italy.
Tiziana CasoliCenter of Biogerontology, IRCCS INRCA, Ancona, Italy.
Giuseppe PelliccioniNeurology Unit, IRCCS INRCA, Ancona, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alzheimer's disease (AD) is the most common neurodegenerative disorder in older adults, characterized by progressive cognitive decline that ultimately leads to severe dementia. The primary pathophysiological hallmarks of AD include the accumulation of amyloid-β plaques, neurofibrillary tangles composed of hyperphosphorylated tau protein, synaptic dysfunction, and pronounced neuroinflammation. Although the exact relationship between neuroinflammation and AD pathogenesis remains incompletely understood, neuroinflammation is consistently recognized as an early and sustained feature of the disease. Accumulating evidence suggests that microbial infections, such as herpes simplex virus type 1, varicella-zoster virus, and

Indexed as

Alzheimer DiseaseNeuroinflammatory DiseasesAnimalsBlood-Brain BarrierBrainDysbiosisGastrointestinal MicrobiomeHumansInflammationAlzheimer’s diseaseblood-brain barrierinfectious pathogensmicrobiota-gut-brain axisneuroinflammation

Identifiers

PMID42835465
PMCPMC13635923

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.