ArticleJournal of the Endocrine Society2026
Cross-sectional evaluation of anthropometric measures vs MRI-measured visceral and hepatic fat in a Canadian cohort.
Article in Journal of the Endocrine Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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20 authors.
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Abstract
Context: Accurate assessment of excess body fat and its cardiometabolic risk is essential in clinical and epidemiologic research. Body-mass index (BMI), although widely used, does not capture visceral or ectopic fat. Objective: To evaluate how anthropometric measures-BMI, percent body fat, waist circumference (WC), and waist-to-hip ratio (WHR)-relate to MRI-measured visceral adipose tissue (VAT) and hepatic fat fraction (HFF), overall, and by sex. Design: Cross-sectional analysis within the Canadian Alliance for Healthy Heart and Minds cohort. Setting: Community-based, pan-Canadian prospective study. Patients or Other Participants: 6683 apparently healthy adults (mean age 57 ± 9 years; 3665 females) with baseline anthropometric and MRI measures; analyses adjusted for study center. Interventions: Not applicable. Main Outcome Measures: MRI-derived VAT and HFF. Associations were estimated using linear regression and mixed models, stratified by sex, ethnicity, age, and BMI category. Results: Mean BMI was 26.7 kg/m Conclusion: WC is a robust surrogate for visceral and hepatic fat across BMI categories, supporting its use when MRI is not feasible.
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