ArticleRSC medicinal chemistry2026
Relationship between nanoscale assembly and cytotoxicity in the piperazine amides of betulinic acid: an
Article in RSC medicinal chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
6 authors.
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Abstract
Six new piperazine amides of betulinic acid, partly decorated with a glycine unit, were synthesized and purified and their structures were elucidated. This study explored whether relationships could be identified among the molecular structures, nanoscale self-assembly, and cytotoxicity of the synthesized compounds. Because of the limited quantities of the target compounds finally available for the analytical methods, their selection had to be very careful. NMR spectroscopy and mass spectrometry were used to elucidate the molecular structures, while transmission electron microscopy (TEM) was employed to characterize the supramolecular structures formed after dissolution in methanol and water. The target compounds reproducibly displayed several basic morphologies depending on the solvent type (methanol
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