ArticleNeuro-oncology advances
Neuro-ophthalmological disturbances in pediatric posterior fossa tumors: Prevalence, risk factors, and outcomes.
Article in Neuro-oncology advances. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Neuro-ophthalmological disturbances present frequently in pediatric posterior fossa (PF) tumors, contributing significantly to morbidity. This study evaluates their prevalence, risk factors, and outcomes in affected children. Methods: This retrospective study analyzed 119 children with PF tumors treated over a decade at a tertiary care center, including 94 presenting at initial diagnosis and 25 at relapse. Clinical and ophthalmologic evaluations were performed preoperatively and 3 months, 1 year, and 2 years postoperatively. Prevalence of visual disturbances, central and/or peripheral oculomotor dysfunctions, optic nerve changes, and corrective ophthalmological interventions, were evaluated over time. Associations between visual/oculomotor outcomes and tumor location, histology, hydrocephalus, cerebellar mutism syndrome (CMS), and intraventricular chemotherapy were analyzed using χ Results: At diagnosis, Conclusions: Neuro-ophthalmological disturbances are common in pediatric PF tumors and evolve throughout treatment. Regular ophthalmologic examinations, including detailed orthoptic assessments, are essential for timely intervention.
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