ArticleFrontiers in microbiology2026
Cytotoxicity of antimicrobial wound irrigation solutions and antiseptics: an
Article in Frontiers in microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
6 authors.
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Abstract
Introduction: Topical antiseptics must control wound bioburden without damaging cells required for tissue repair, yet cytocompatibility data obtained from isolated active compounds or monolayer exposure may not reflect finished formulations under clinically relevant conditions. Methods: This study compared the cytotoxic effects of six commercial antiseptics and wound-irrigation solutions across complementary Results: Cytotoxicity was strongly dependent on formulation, exposure time, concentration, and cell type. Octenidine/Phenoxyethanol caused the greatest and most rapid loss of viability, with substantial effects after 1 min and the most pronounced epithelial disorganization Discussion: Cytocompatibility cannot be inferred from antiseptic class or nominal active-agent concentration alone. Finished formulations should be evaluated across various clinically relevant exposure conditions and tissue-level models and product selection should balance antimicrobial efficacy with preservation of regenerative cells and tissue.
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