Evidence map›Paper›PMID 42835342›Full record

ArticleFrontiers in cell and developmental biology2026

Molecular analysis of Aldh1a2 conditional inactivation in developing limbs reveals mechanisms of retinoic-acid mediated interdigital apoptosis.

Rodrigue Peraldi, Yacine Kherdjemil, Gabriel Villiard, Nayuta Yakushiji-Kaminatsui, Marie Kmita

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In one paragraph

Article in Frontiers in cell and developmental biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Rodrigue PeraldiGenetics and Development Research Unit, Institut de Recherches Cliniques de Montréal, Montréal, QC, Canada.
Yacine KherdjemilPlateforme Modélisation des Maladies et édition Du Génome, Institut de Recherches Cliniques de Montréal, Montréal, QC, Canada.
Gabriel VilliardGenetics and Development Research Unit, Institut de Recherches Cliniques de Montréal, Montréal, QC, Canada.
Nayuta Yakushiji-KaminatsuiLaboratory for Developmental Genetics, RIKEN Center for Integrative Medical Sciences (IMS), Yokohama, Japan.
Marie KmitaGenetics and Development Research Unit, Institut de Recherches Cliniques de Montréal, Montréal, QC, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Retinoic acid (RA) plays a plethora of functions during embryonic development as well as post-natal life. In particular, RA function during limb development is associated with interdigital cell death. However, the molecular mechanism(s) through which RA signaling contributes to interdigital cell death remains poorly understood. Methods: To gain insights into the mechanism(s) involved, we used a conditional approach to inactivate the RA catalyzing enzyme Aldh1a2 thereby abrogating RA signaling in the distal limb. Results and Discussion: Our data first show that

Indexed as

ALDH1A2digit patterninginterdigital apoptosislimb developmentretinoic acid

Identifiers

PMID42835342
PMCPMC13635163

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.