ArticleFrontiers in endocrinology2026
From metabolic network to brain loop: unraveling the neuro-metabolic correlates in PCOS-related depression.
Article in Frontiers in endocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aim: Polycystic ovary syndrome(PCOS) is increasingly recognized for its substantial depressive burden, however, the underlying mechanism remains unclear. In this study, the neuro-metabolic pathway was explored to unravel the mechanism in PCOS-related depression. Methods: Participants recruited from the UK Biobank comprised a cross-sectional population, the outcome as female depression, with 2,826 individuals among whom 471 diagnosed with PCOS. Progressive regression, interaction and mediation analyses, linearity and threshold examinations, relative weight analysis and principal component analysis(PCA), as well as stratified analyses were conducted in this study. Results: The two brain magnetic resonance imaging(MRI) metrics as volume of grey matter in frontal orbital cortex(FOC GMVol) and mean thickness of caudalanteriorcingulate(CaudalAntCing Thk) showed prominent links with PCOS-related depression, with CaudalAntCing Thk serving as the final common executor to depression. FOC GMVol and CaudalAntCing Thk interacted with PCOS in a metabolic-dependent and a metabolic-independent way respectively. A PCOS×free androgen index(FAI)×FOC GMVol three-way interaction was observer only in normal body mass index(BMI) individuals with high FAI. The FOC GMVol-CaudalAntCing Thk association, correlated with concurrent increases in BMI and FAI, existed exclusively in non-PCOS. Metabolic factors exhibited mediating effects (BMI and FAI) and formed a network among which BMI served as a hub linking the antagonistic FAI and the auxiliary triglyceride-glucose index(TyG), while systemic immune-inflammation index(SII) acted as an independent risk factor irrelevant to PCOS. A two-tiered brain protective hypothesis was proposed against depression: neural compensation reflected the protective FOC GMVol-CaudalAntCing Thk coupling in non-PCOS, and protective threshold patterns of both FOC GMVol and CaudalAntCing Thk in PCOS, with FAI playing pivotal and distinct roles at both peripheral and central levels across the entire pathways. Conclusion: Given the intricate neuro-metabolic correlates underlying PCOS-related depression, further studies were warranted and a synergistic therapeutic strategy of androgen suppression plus weight management might be considered.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.