Evidence map›Paper›PMID 42835275›Full record

ArticleiScience2026

VWA2 fuels colon cancer growth and immune evasion through Wnt/β-catenin signaling.

Yanlin He, Jiang Chen, Huaqian Dong, Xiuya Ren, Tian Tian, Wei Xie, Tao Yang

Abstract read
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yanlin HeColorectal and Anal Surgery, the First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, No. 71 Baoshan North Road, Yunyan District, Guiyang 550001, China.
Jiang ChenColorectal and Anal Surgery, the First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, No. 71 Baoshan North Road, Yunyan District, Guiyang 550001, China.
Huaqian DongDepartment of Nursing, the First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, No. 71 Baoshan North Road, Yunyan District, Guiyang 550001, China.
Xiuya RenDepartment of Nursing, the First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, No. 71 Baoshan North Road, Yunyan District, Guiyang 550001, China.
Tian TianDepartment of Nursing, the First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, No. 71 Baoshan North Road, Yunyan District, Guiyang 550001, China.
Wei XieDepartment of Nursing, the First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, No. 71 Baoshan North Road, Yunyan District, Guiyang 550001, China.
Tao YangColorectal and Anal Surgery, the First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, No. 71 Baoshan North Road, Yunyan District, Guiyang 550001, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Colon adenocarcinoma (COAD) progression involves complex interactions between tumor cell intrinsic pathways and immune evasion. Here, we show that VWA2 is markedly upregulated in COAD and correlates with poor prognosis across multiple cancer types. Using patient-derived data, cell-based assays, and

Indexed as

CD8+ T cellCEMIPcolon adenocarcinomaVWA2β-catenin

Identifiers

PMID42835275
PMCPMC13635522

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.