ArticleFrontiers in pharmacology2026
Determinants of off-label drug acceptance in pregnancy: insights from an extended UTAUT model.
Article in Frontiers in pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Off-label drug use (OLDU) is prevalent in obstetrics due to the scarcity of medications approved for pregnancy, raising potential risks and ethical challenges, particularly concerning informed consent. In this study, we aimed to identify the key determinants of OLDU acceptance among pregnant women using an extended Unified Theory of Acceptance and Use of Technology (UTAUT) model. Methods: A cross-sectional survey of 506 pregnant women was conducted at a tertiary hospital using a validated UTAUT-based questionnaire. Multivariable linear regression identified factors associated with behavioral intention. Six perceived risk-by-subgroup interactions were tested, with Results: A total of 57.51% of participants were willing to accept OLDU when recommended by a doctor, whereas only 46.44% had understood the definition prior to the study. In the multivariable regression, trust showed the strongest positive association with behavioral intention (B = 0.380, β = 0.377, and Conclusion: The findings highlight the importance of trust and facilitating conditions in OLDU acceptance. The positive association between perceived risk and behavioral intention indicates that recognition of potential risks and willingness to accept treatment are not necessarily mutually exclusive in this clinical decision-making context, although the explanation for this association remains uncertain. This study supports the utility of the extended UTAUT model for understanding high-risk medical decisions and underscores the importance of trust-building and transparent benefit-risk communication in clinical practice.
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