Evidence map›Paper›PMID 42835247›Full record

ArticleiScience2026

Temporal and transcriptional programming of effector memory B cells shapes vaccine platform-dependent humoral immunity.

Anoma Nellore, Christopher Fucile, Christopher D Scharer, Page Murray, Jack T Geer, Jacey Lemonds, Betty Mousseau, Fen Zhou, Esther Zumaquero, Jobaida Akhter and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Anoma NelloreDivision of Infectious Diseases NYU Langone, New York, NY, USA.
Christopher FucileDepartment of Bioinformatics UAB, Birmingham, AL, USA.
Christopher D ScharerDepartment of Microbiology, Emory, Atlanta, GA, USA.
Page MurrayVilcek Institute of Biomedical Sciences, NYU Langone, New York, NY, USA.
Jack T GeerDivision of Infectious Diseases UAB, Birmingham, AL, USA.
Jacey LemondsDivision of Infectious Diseases UAB, Birmingham, AL, USA.
Betty MousseauDepartment of Microbiology UAB, Birmingham, AL, USA.
Fen ZhouDepartment of Microbiology UAB, Birmingham, AL, USA.
Esther ZumaqueroDepartment of Microbiology UAB, Birmingham, AL, USA.
Jobaida AkhterDivision of Clinical Immunology/Rheumatology UAB, Birmingham, AL, USA.
Ellie IvanovaDepartment of Pathology NYU Langone, New York, NY, USA.
Valeria Estrada NavarroVilcek Institute of Biomedical Sciences, NYU Langone, New York, NY, USA.
Paul A GoepfertDivision of Infectious Diseases UAB, Birmingham, AL, USA.
Ralf DuerrDivision of Infectious Diseases NYU Langone, New York, NY, USA.
Ramin S HeratiDivision of Infectious Diseases NYU Langone, New York, NY, USA.
Alexander D RosenbergDepartment of Bioinformatics UAB, Birmingham, AL, USA.
Frances E LundDepartment of Microbiology UAB, Birmingham, AL, USA.
Troy D RandallDivision of Clinical Immunology/Rheumatology UAB, Birmingham, AL, USA.

Funding

CTSA UM1 at the University of Alabama at BirminghamUM1TR004771 · NCATS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI PATRICE DELAFONTAINE, Orlando M Gutierrez · 2024 to 2026
$29.2M
Virus-induced Cell Fate Decisions in Anti-Viral ImmunityU19AI109962 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI RANDALL, TROY D · 2014 to 2018
$11.6M
NCATS NIH HHS UM1 TR004771NIAID NIH HHS U19 AI109962
6 · The paper itself

Abstract

This study investigates how influenza vaccine platform shapes the memory B cell responses that underlie durable antibody protection. Using fluorescent hemagglutinin (HA) probes, the authors compared HA-specific IgD-negative B cells in adults who received either live attenuated influenza vaccine (LAIV) or inactivated influenza vaccine (IIV). Both platforms induced circulating T-bet

Indexed as

B cellinfluenzamemoryvaccine

Identifiers

PMID42835247
PMCPMC13635500

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.