ReviewIranian journal of medical sciences2026
Hyaluronic Acid in Spinal Disorders: A Narrative Review of Hot Spots and Research Perspectives.
Review in Iranian journal of medical sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hyaluronic acid (HA), a cell behavior modulator with anti-aging, anti-inflammatory, and immunomodulatory properties, is a member of the glycosaminoglycan family. In orthopedics, HA has been utilized for its chondroprotective, anti-inflammatory, immunomodulatory, and cushioning effects, owing to its extreme lubricity and hydrophilicity. HA has been investigated for various diagnostic and therapeutic applications in spinal diseases. This narrative review aimed to clarify that HA may serve as a biomarker in spinal diseases and as a therapeutic agent in several applications, such as tissue engineering for intervertebral disc degeneration, management of spinal pain, prevention of postoperative epidural fibrosis, and minimally invasive treatment of vertebral compression fractures. Although the efficacy of HA as a viable alternative or adjunct to existing therapies for various spinal conditions has been investigated, further experimental and clinical studies are required to explore regulatory considerations, refine clinical applications, and develop potential interdisciplinary management strategies before general recommendations can be established.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.