ArticleSexual medicine2026
Inflammatory burden index predicts arteriogenic erectile dysfunction: a mediation analysis involving the TyG index.
Article in Sexual medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Inflammation and metabolic dysregulation play important roles in the pathophysiology of erectile dysfunction. The inflammatory burden index (IBI), a composite biomarker integrating C-reactive protein (CRP), neutrophils, and lymphocytes, has emerged as a marker of systemic inflammatory load. However, the association between IBI and arteriogenic erectile dysfunction (AED) remains largely unexplored. To investigate the association between IBI and AED and to examine whether insulin resistance (IR), assessed by the triglyceride-glucose (TyG) index, mediates this relationship. Methods: In this cross-sectional study, men aged 18-65 years were consecutively recruited from the local hospital between April 2023 and November 2025. Erectile function was assessed using the 5-item International Index of Erectile Function (IIEF-5), nocturnal penile tumescence and rigidity monitoring, and penile color Doppler ultrasonography. Multivariable logistic regression models were applied to evaluate the association between IBI and AED. Receiver operating characteristic curves were used to assess the predictive performance of inflammatory markers. Mediation analysis was conducted to explore the potential mediating role of IR using the TyG index. Results: A total of 211 participants were included (109 AED; 102 controls). Patients with AED exhibited significantly higher inflammatory indices, including CRP, neutrophil-to-lymphocyte ratio (NLR), and IBI. In multivariable analysis, IBI remained independently associated with AED (OR = 1.626, 95% CI, 1.326-1.994, Conclusion: Elevated IBI is independently associated with AED, and IR partially mediates this relationship, suggesting a potential inflammatory-metabolic pathway that may be involved in vascular erectile impairment, although causality cannot be established due to the cross-sectional design.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.