ArticleFrontiers in medicine2026
IgG4-related kidney disease mimicking renal cell carcinoma: a case report and literature review.
Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
IgG4-related kidney disease (IgG4-RKD) presenting as renal masses is a very rare clinical entity. IgG4-RKD represents the renal manifestation of IgG4-related disease (IgG4-RD) and is characterized primarily by tubulointerstitial nephritis (TIN) caused by infiltration of IgG4-positive plasma cells in the renal interstitium and tubules. Typical imaging findings include renal enlargement and cortical low-density lesions; however, a very small proportion of IgG4-RKD cases may present as space-occupying renal lesions, which are easily misdiagnosed as renal malignancies. In this report, we describe a patient hospitalized for a respiratory disease whose abdominal computed tomography (CT) scan (non-contrast, contrast-enhanced, and 3D reconstruction) revealed a space-occupying lesion in the right kidney, with no significant abnormalities in the left kidney. Clinicians initially suspected a malignant renal tumor and proceeded with radical nephrectomy of the right kidney. Postoperative histopathology and immunohistochemistry confirmed the diagnosis of IgG4-RKD.
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