Mannan-oligosaccharides-based self-assembly nanoparticles enable gut-specific quercetin release, providing multi-pathway protection against AD via gut-brain axis.

Guifeng Zhang, Hongjiang Li, Wei Zhang, Dan Pu, Longxing Wang, Xiaofei Han, Ju Wu

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Article in Journal of pharmaceutical analysis, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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7 authors.

Guifeng ZhangCollege of Life and Health of Dalian University, Affiliated Zhongshan Hospital of Dalian University, Dalian, Liaoning, 116622, China.

Hongjiang LiSchool of Environmental and Chemical Engineering, Dalian University, Dalian, Liaoning, 116622, China.

Wei ZhangCollege of Life and Health of Dalian University, Affiliated Zhongshan Hospital of Dalian University, Dalian, Liaoning, 116622, China.

Dan PuCollege of Life and Health of Dalian University, Affiliated Zhongshan Hospital of Dalian University, Dalian, Liaoning, 116622, China.

Longxing WangDalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, Liaoning, 116023, China.

Xiaofei HanCollege of Life and Health of Dalian University, Affiliated Zhongshan Hospital of Dalian University, Dalian, Liaoning, 116622, China.

Ju WuCollege of Life and Health of Dalian University, Affiliated Zhongshan Hospital of Dalian University, Dalian, Liaoning, 116622, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mannan-oligosaccharides (MOS), as indigestible functional prebiotic, support intestinal health. Here, we engineered MOS to undergo linoleic acid (LA)-mediated self-assembly with quercetin, forming lipid bilayer nanoparticles (MOS-LA/LA-Q NPs). These nanoparticles (NPs) achieved a high quercetin encapsulation efficiency (92.4%) and demonstrated superior stability in aqueous solution at 4 °C. The MOS outer layer effectively protected the quercetin core from gastrointestinal stress. Triggered by microbial enzymes, the system enabled a sustained quercetin release, up to 60% over 48 h, representing a novel microbe-specific delivery mechanism. In an Alzheimer's disease (AD) mice models induced by AlCl

Indexed as

Alzheimer's diseaseCognitive functionGut-brain axisLinoleic acidMannan oligosaccharideQuercetinSelf-assembled nanoparticles

Identifiers

PMID42835137

DOI10.1016/j.jpha.2026.101737

PMCPMC13635266

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.