ReviewiScience2026
Interplay between SFTSV and host innate immunity: Viral evasion mechanisms, pathogenesis, and therapeutic perspectives.
Review in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Severe fever with thrombocytopenia syndrome (SFTS), caused by SFTSV, is an emerging tick-borne disease with substantial mortality in East Asia and increasing geographic reach. Here, we provide an updated conceptual framework that integrates classic host recognition via DNA and RNA sensors accompanied with the multifaceted immune evasion strategies orchestrated by the viral components. A central focus is that SFTSV utilizes host receptors for attachment and internalization while hijacking autophagy-related membranes to promote assembly and egress. Its NSs protein forms autophagic inclusion bodies that sequester and degrade innate immune factors, whereas NP and Gn interfere with RIG-I-MAVS and cGAS-STING signaling through autophagy-associated mechanisms. We also examine NS-driven inflammatory regulation and evidence that the microbiota shapes virus transmission and antiviral responses. Collectively, unraveling these intricate host-virus interactions will be pivotal for advancing targeted therapeutic strategies against SFTS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.