ArticleFrontiers in endocrinology2026
Objective assessment of transition hyperactivated motility in 10-μm chambers: a functional predictor of sperm recovery in assisted reproduction.
Article in Frontiers in endocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Conventional sperm motility analysis often fails to capture the dynamic physiological changes associated with fertilization. The identification of a transition hyperactivated (TH) phenotype, characterized by high vigor while preserving linearity, may provide additional information on ejaculate functional competence beyond standard semen parameters. Objective: To establish an objective method for detecting TH motility using computer-assisted sperm analysis (CASA) with 10-μm chambers and to evaluate its clinical predictive value in comparison with pharmacological induction. Materials and methods: The Sperm Class Analyzer (SCA) system (Microptic SL) was validated using the following kinematic thresholds: curvilinear velocity (VCL) > 35 μm/s, linearity (LIN) > 50%, and amplitude of lateral head displacement (ALH) > 2.5 μm. Semen samples from fertile men ( Results: Significant differences were observed among the analyzed conditions (Kruskal-Wallis test with Conover Conclusion: Transition hyperactivated motility represents a novel and objective functional biomarker of sperm kinematic competence beyond conventional semen parameters. Measurement of THE in 10-μm chambers provides a robust analytical approach for functional sperm assessment. Combined with T4 induction, this strategy may offer clinically relevant information on sperm functional status. Prospective studies including pregnancy outcomes are needed to determine its predictive value for clinical fertility and assisted reproduction.
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